Preparation and Characterization of 4,4′-Dibromo -6,6′- bis(N,N-bis(ethoxycarbonylmethyl)amino methyl)- 2,2′-bipyridine

doi:10.3724/SP.J.1095.2010.90713

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (09): 1008-1011.DOI: 10.3724/SP.J.1095.2010.90713

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Preparation and Characterization of 4,4′-Dibromo -6,6′- bis(N,N-bis(ethoxycarbonylmethyl)amino methyl)- 2,2′-bipyridine

LI Yun-Hui¹, LI Hai-Yan¹, PAN Li-Hua^2*, XU Jing-Wei², CHANG Yu², DI Yan-Qing¹, LIU Wen-Yu¹

(1.School of Chemistry and Environmental Engineering,Changchun University
of Science and Technology,Changchun；
2.National Analytical Research Center of Electrochemistry and Spectroscopy,
Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022)

Received:2009-10-30 Revised:2010-03-18 Published:2010-09-10 Online:2010-09-10

Abstract

Abstract:

4,4′-Dibromo-6,6′-bis(N,N-bis(ethoxycarbonylmethyl)amino methyl)-2,2′-bipyridine was prepared from 4,4′-dinitro-6,6′-dimethyl-2,2′-bipyridine N,N-dioxide by esterification with trifluoroacetic anhydride and hydroxymethylation, bromine methylation with HBr, and methylation of amino hydrogen with diethyl iminodiacetate. The structure of this product was determined by DSC, IR, 1H NMR, HPLC and HRMS. The obtained product is an important intermediate for the synthesis of a bi-functional chelate, which could find applications in solid phase time resolved fluoroimmunoassay.

Key words: time-resolved fluorescence immunoassay, chelate, intermediate, dibromo-bis(bromomethyl)-bipyridine, dibromo-bis(N,N-bis(ethoxycarbonylmethyl)amino methyl)-bipyridine, synthesis

CLC Number:

O621.3

LI Yun-Hui1, LI Hai-Yan1, PAN Li-Hua2*, XU Jing-Wei2, CHANG Yu2, DI Yan-Qing1, LIU Wen-Yu1. Preparation and Characterization of 4,4′-Dibromo -6,6′- bis(N,N-bis(ethoxycarbonylmethyl)amino methyl)- 2,2′-bipyridine[J]. Chinese Journal of Applied Chemistry, 2010, 27(09): 1008-1011.

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Preparation and Characterization of 4,4′-Dibromo -6,6′- bis(N,N-bis(ethoxycarbonylmethyl)amino methyl)- 2,2′-bipyridine

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