Synthesis, Characterization and Antibacterial Activity of 3-Substituted-6-(4′-decarboxydehydroabietyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives

doi:10.3724/SP.J.1095.2010.90513

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (06): 651-657.DOI: 10.3724/SP.J.1095.2010.90513

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Synthesis, Characterization and Antibacterial Activity of 3-Substituted-6-(4′-decarboxydehydroabietyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives

SU Gui-Fa¹*, ZHOU Yi-Ming¹, QIN Jiang-Ke¹, DENG Ye-Cheng², ZHANG Ming², WANG Zhong-Chang¹, ZONG Xi¹

(1.Key Laboratory for the Chemistry and Molecular Engineering of Medicial Resources of State Education
Ministry,College of Chemistry & Chemical Engineering,Guangxi Normal University,Guilin 541004;
2.College of Life Science,Guangxi Normal University,Guilin 541004)

Received:2009-07-30 Revised:2009-12-30 Published:2010-06-10 Online:2010-06-10
Contact: Guifa SU

Abstract

Abstract:

Fourteen new 3-substituted-6-(4′-decarboxydehydroabietyl)-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles 5a~5e and 11a~11i were obtained from the reaction of 3-substituted-4-amino-5-mercapto-1,2,4-triazoles 4 and 10 with dehydroabietic acid ]1 in the presence of phosphorus oxychloride, respectively. All target compounds were characterized by IR, 1H NMR, 13C NMR and MS. The preliminary antibacterial activity assay showed that title compounds 5 and 11 exhibited a fungicidal activity against C.Albicans, E.coli., M.Luteus and S.Dysenteriae.

Key words: dehydroabietic acid, triazolo[3,4-b]-thiadiazole, antibacterial activity

CLC Number:

O626.2

SU Gui-Fa1*, ZHOU Yi-Ming1, QIN Jiang-Ke1, DENG Ye-Cheng2, ZHANG Ming2, WANG Zhong-Chang1, ZONG Xi1. Synthesis, Characterization and Antibacterial Activity of 3-Substituted-6-(4′-decarboxydehydroabietyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives[J]. Chinese Journal of Applied Chemistry, 2010, 27(06): 651-657.

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Synthesis, Characterization and Antibacterial Activity of 3-Substituted-6-(4′-decarboxydehydroabietyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives

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