Abstract:

The active intermediate that substitution-4-formacyl pyrazole were obtained from benzene hydrazone via the Vilsmeier-Haak reaction. Then they reacted with 4-substituted aryloxyacetyl hydrazine to form the compounds 3. Finally Bis-heterocyclic compound 4 were synthesized via cyclic reaction. All newly synthesized compounds have not been reported and their structures have been established on the basis of IR, 1H NMR, Ms spectral data and elemental analysis. The compound 3,4 conducted a preliminary test of antibacterial activity about Fusarium oxyaporium、Verticillium dahliae、Rhizoctonia solani、Pychium aphanidermatum、Alternaria solani、Sclerotinia sclerotiorum. The results showed that the inhibiting rate of the Bis-heterocyclic compounds 4 higher than the pyrazole hydrazones 3 obviously. Compounds 3d、3e showed good inhibitory activities (﹥80%) against Alternaria solani and Sclerotinia sclerotiorum at a concentration of 50 mg/L. In contrast, Bis-heterocyclic Compounds 4 have obviously inhibitory activities (﹥70%) against these six germ and compounds 4d、4e showed inhibitory activities (﹥95%) against Rhizoctonia solani .

Key words: pyrazole, oxadiazole, synthesis, fungicidal activity