Chinese Journal of Applied Chemistry ›› 2009, Vol. 26 ›› Issue (08): 885-889.

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Synthesis and Biological Activity of Triazolopyrimidine Diheterocyclic Thio-Ether Derivatives

MA Zhong-Hua1,2,CHEN Qiong2*   

  1. (1.College of Basic Sciences,Huazhong Agricultural University,Wuhan;
    2.College of Chemistry,Central China Normal University,Wuhan 430079)
  • Received:2008-07-17 Revised:2008-11-25 Published:2009-08-10 Online:2009-08-10

Abstract:

Ten novel diheterocyclic thio-ether compounds containing 1, 2, 4-triazolo[1, 5-a] pyrimidine and 1, 2, 4-triazole moieties were designed and synthesized by using 2-mercapto-5, 7-dimethyl-[1, 2, 4]triazolo[1, 5-a]pyrimidine as starting material. All compounds obtained were comfired by MS and 1H NMR, Preliminary biological activity indicates most compounds 6 display good activity against C. beticola. Especially, 6b, 6e, 6f, 6g, 6h at the concentration of 50×10-6 g/ can reach grade A (≥90%).

Key words: triazolopyrimidine, triazolo, synthesis, biological activity

CLC Number: