Abstract:

Ten novel diheterocyclic thio-ether compounds containing 1, 2, 4-triazolo[1, 5-a] pyrimidine and 1, 2, 4-triazole moieties were designed and synthesized by using 2-mercapto-5, 7-dimethyl-[1, 2, 4]triazolo[1, 5-a]pyrimidine as starting material. All compounds obtained were comfired by MS and 1H NMR, Preliminary biological activity indicates most compounds 6 display good activity against C. beticola. Especially, 6b, 6e, 6f, 6g, 6h at the concentration of 50×10-6 g/ can reach grade A (≥90%).

Key words: triazolopyrimidine, triazolo, synthesis, biological activity