Preparation and Release Behavior of Ibuprofen Intercalated Hydrotalcite/Starch Gel Composites

doi:10.11944/j.issn.1000-0518.2018.07.170291

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (7): 781-787.DOI: 10.11944/j.issn.1000-0518.2018.07.170291

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Preparation and Release Behavior of Ibuprofen Intercalated Hydrotalcite/Starch Gel Composites

Lei YANG(),Yunxing ZHANG,Xiaoqin WANG

College of Environmental and Biological Engineering,Fujian Provincial Key Laboratory of Ecology-Toxicological Effects & Control for Emerging Contaminants,Putian University,Putian,Fujian 351100,China

Received:2017-08-21 Accepted:2018-01-05 Published:2018-07-06 Online:2018-07-06
Contact: Lei YANG
Supported by:
Supported by the National Natural Science Foundation of China(No.31400318), the University Industry-Academy Cooperation Project of Fujian Provincial Science and Technology Department(No.2015H6017), the Project of Fujian Provincial Key Laboratory of Ecology-Toxicological Effects & Control for Emerging Contaminants(No.PY16012), the National College Students Innovation Project(No.201611498015, No.201711498025)

Abstract

Abstract:

To provide experimental basis for the design of new ibuprofen(IBU) sustained release system, the layered double hydroxide-ibuprofen intercalation compound(LDH-IBU), the starch gel-ibuprofen(starch gel-IBU) compound and layered double hydroxide/starch gel-ibuprofen(LDH/starch gel-IBU) intercalation compound were prepared by co-precipitation, roasting reduction and freeze-thaw methods based on magnesium chloride hexahydrate, aluminum chloride hexahydrate, IBU and starch as raw materials. The structures of three kinds of above composites were characterized by Fourier transform infrared spectrometer(FT-IR) and X-ray diffractometer(XRD). Their controlled release properties under the condition of simulated human body environment were studied. The results show that IBU in three kinds of complexes in different release media has certain controlled release effect. The release rates decrease in the order of LDH/starch gel-IBU, LDH-IBU and starch gel-IBU. The release rates in 3 buffer media decrease in the order of pH=6.6, pH=7.4 and 0.9% normal saline. The release kinetics can be fitted to the pseudo-first order kinetic model.

Key words: layered double hydroxides, starch gel, ibuprofen, intercalation, controlled release

Lei YANG, Yunxing ZHANG, Xiaoqin WANG. Preparation and Release Behavior of Ibuprofen Intercalated Hydrotalcite/Starch Gel Composites[J]. Chinese Journal of Applied Chemistry, 2018, 35(7): 781-787.

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Preparation and Release Behavior of Ibuprofen Intercalated Hydrotalcite/Starch Gel Composites

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