The Synthesis of Bichalcone Rhuschalcone I

doi:10.3724/SP.J.1095.2011.00427

Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (06): 652-656.DOI: 10.3724/SP.J.1095.2011.00427

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The Synthesis of Bichalcone Rhuschalcone I

ZHANG Yingpeng^*, CHEN Yutao, YANG Yunshang, GUAN Xiao

(Institute of Organic & Pharmaceutical Chemistry,School of Petrochemical Engineering,
Lanzhou University of Technology,Lanzhou 730050)

Received:2010-07-22 Revised:2010-08-31 Published:2011-06-10 Online:2011-06-10

Abstract

Abstract:

Rhuschalcone Ⅰ was adopted to two synthetic fragments, compound 8 and compound 10, then the two fragments were combined together. Rhuschalcone Ⅰ were first synthesized by selective methylation, iodination, methoxymethylation, aldol condensation, Ullmann reaction, deprotection from m-dihydroxybenzene and p-hydroxybenzaldehyde. The chemical structures of the key intermediate and the final target product were verified by 1H NMR, 13C NMR and ESI-MS.

Key words: RhuschalconeⅠ, Ullmann reaction, Total synthesis, Aldol condensation

CLC Number:

O625

ZHANG Yingpeng*, CHEN Yutao, YANG Yunshang, GUAN Xiao. The Synthesis of Bichalcone Rhuschalcone I[J]. Chinese Journal of Applied Chemistry, 2011, 28(06): 652-656.

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The Synthesis of Bichalcone Rhuschalcone I

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