Abstract:

In order to find more stable and effective antibacterial compounds, we screened some N-(5-chloro-2-hydroxybenzyl) amino acid ester with good antibacterial activities. Twenty metal-amino complexes with 1∶1 molar ratio of ligand to metal cation were synthesized via a step-by-step method in alkaline aqueous solutions or water-methanol mixed solvents at room temperature. These complexes and the structures of the compounds were confirmed by 1H NMR, IR and UV. It was found that the hydroxyl group, amine group and carboxyl group of ligands could coordinate with metal cations. Preliminary bioassay results showed that nearly all the metal complexes have better anti-bacteria activities than their counterpart ligands, especially for the Monilia-albicans which has a 100% inhibitory ratio. The conditions of the preparation of N-(5-chloro-2-hydroxyphenyl) amino acid ester schiff-base were optimized.

Key words: N-(chloro-hydroxylbenzyl) amino acid /ester, coordination compounds, antibacterial property