Abstract:

N,N-Dimethylformamide-dimethyl acetal(DMF-DMA) was refluxed with the corresponding aromatic or heterocyclic compounds to prepare the intermediates 3-(dimethylamino)-1-(substituted)prop-2-en-1-one with a yield of 71.2%~85.2%. By refluxing the obtained intermediates with guanidine hydrochloride in ethanol and in the presence of sodium ethoxide, fourteen 4-substituted-2-amino-pyrimidines were obtained in good yield of 66.6%~86.1%. All the products were confirmed by NMR, mass spectrometry, and elemental analysis.

Key words: substituted-amino-pyrimidines, synthesis, characterization