Abstract:

The organotin compound {[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2 was synthesized by the reaction of di(o-methylbenzyl)tin dichloride with N-(o-methylbenzyl)hydroxylamine. It’s structure has been determined by X-ray single crystal diffraction. Crystallorgaphic for the compound: Triclinic, P-1, a =1.0604(5) nm，b =1.3078(7) nm，c = 1.3742(47 nm，α=105.174(12)?，β = 90.229(7)?，γ=101.028(6)?，Z = 1，V =1.8025(15) nm3，Dc=1.522Mg•m-3，?(MoKa)= 1.423 mm-1，F(000)= 834，R1=0.0455，wR2=0.1017. In the compound, the tin ions are five-coordinated and exhibit distorted trigonal bipyramidal geometries.The complrx has a ladder-like structure, which is composed by three Sn2O2 planes. The brief investigation shows that this tin compound is antitumour activity in vitro against WiDr and MCF-7 tumour cells.

Key words: di(o-methylbenzyl)tin dichloride, N-(o-methylbenzyl)hydroxylamine, synthesis, crystal structure, antitumour activity