Chinese Journal of Applied Chemistry ›› 2009, Vol. 26 ›› Issue (6): 662-666.

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Synthesis, Crystal Structure and Properties of Organotin Compound{[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2

  

  • Received:2008-06-17 Revised:2008-10-09 Published:2009-06-10 Online:2009-06-10

Abstract:

The organotin compound {[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2 was synthesized by the reaction of di(o-methylbenzyl)tin dichloride with N-(o-methylbenzyl)hydroxylamine. It’s structure has been determined by X-ray single crystal diffraction. Crystallorgaphic for the compound: Triclinic, P-1, a =1.0604(5) nm,b =1.3078(7) nm,c = 1.3742(47 nm,α=105.174(12)?,β = 90.229(7)?,γ=101.028(6)?,Z = 1,V =1.8025(15) nm3,Dc=1.522Mg•m-3,?(MoKa)= 1.423 mm-1,F(000)= 834,R1=0.0455,wR2=0.1017. In the compound, the tin ions are five-coordinated and exhibit distorted trigonal bipyramidal geometries.The complrx has a ladder-like structure, which is composed by three Sn2O2 planes. The brief investigation shows that this tin compound is antitumour activity in vitro against WiDr and MCF-7 tumour cells.

Key words: di(o-methylbenzyl)tin dichloride, N-(o-methylbenzyl)hydroxylamine, synthesis, crystal structure, antitumour activity

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