Chinese Journal of Applied Chemistry ›› 1995, Vol. 0 ›› Issue (2): 13-15.

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Synthesis and Antitumor Activity of Schiff Base Coordination Compounds

Yang Gaowen, Xia Xiaoping, Tu Huan, Zhao Chenxue   

  1. Department of Chemistry, Huazhong University of Science and Technology, Wuhan, 430074
  • Received:1994-07-01 Revised:1994-09-30 Published:1995-04-10 Online:1995-04-10

Abstract: A series of Schiff base coordination compounds containing Cu,Ni,Zn,and Co has been synthesized from salicylaldehyde,2,4-dihydroxy benzaldehyde,glycine and L-ala-nine. The order of the antitumor activity of the con1pounds is Ni>Cu>Zn>Co,by ethidiumfluorescence spectroscopy.

Key words: Schiff base, imidazole, metal coordination compound, antitumor activity