Abstract: Cu(Salad)₂, Cu(gly)₂H₂O, Cu(o-NH₂C₆H₄CO₂)₂, Cu(ClO₄)₂6H₂O, Cu(CH₃CN)₄ClO₄ were use first time for catalyzing cyclopropanation of ethyl diazoaeetate (EDA) with tetramethyl ethylene (TME). Cu(Ⅱ) amino acid salts showed no catalytic activity, when they were used directly. High catalytic activity appeared only cohen they were pre-reduccd to Cu(Ⅰ) High TME/EDA ratio, high EDA/Cat ratio, longer addition period of EDA-TME mixture, and high reaction temperature benefited the product yield. Cu(salad)₂ and Cu(gly)₂H₂O showed higher catalytic efficiency for the reaction under suitable conditions.

Key words: copper catalyst, tetramethyene, ethyl diazoacetate, cyclopropanation