Chinese Journal of Applied Chemistry ›› 1986, Vol. 0 ›› Issue (6): 68-69.

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DETERMINATION OF PROTON DISSOCIATION CONSTANT OF TRIS-(HYDROXYMETHYL)-AMINOMETHANE BY NMR METHOD

Shi Feng, Xiao Yanwen, Ni Jiazuan   

  1. Changchun Institute of Applied Chemistry, Academia Sinica
  • Received:1985-12-26 Revised:1986-03-10 Published:1986-12-10 Online:1986-12-10

Abstract: The proton dissociation process of tris-(hydroxymethyl)-aminomethane(THAM) has been studied by 1H and 13C NMR methods.The proton dissociation constant of the title compound determined was pK=8,15, which was in good agreement with the re-sults obtained by other methods in the literature.