One Pot Continuous Reaction of Benzoin Condensation and Allylic Nucleophilic Substitution Using N-Heterocyclic Carbenes and Nickel(Ⅱ) Chloride as Catalysts

doi:10.3724/SP.J.1095.2013.20527

Chinese Journal of Applied Chemistry

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One Pot Continuous Reaction of Benzoin Condensation and Allylic Nucleophilic Substitution Using N-Heterocyclic Carbenes and Nickel(Ⅱ) Chloride as Catalysts

HE Jinmei^*, QU Mengnan, HE Zhongsen

(College of Chemistry and Chemical Engineering,Xi′an University of Science and Technology,Xi′an 710054,China)

Received:2012-11-15 Revised:2012-12-12 Published:2013-07-10 Online:2013-07-10

Abstract

Abstract: With the presence of nickel(Ⅱ) chloride as metal complex catalyst and N-heterocyclic carbene as organic catalyst effective one pot synthesis of allylated α-hydroxy carbonyl compound in 78% yield was developed using benzaldehyde and cinnamyl acetate as precursors in potassium carbonate THF solution. The involved reactions during the continuous reaction are benzoin condensation and allylic nucleophilic substitution.

Key words: nickel(II) chloride, N-heterocyclic carbenes, catalyze, one pot, benzoin condensation, allylic nucleophilic substitution

CLC Number:

O622

HE Jinmei*, QU Mengnan, HE Zhongsen. One Pot Continuous Reaction of Benzoin Condensation and Allylic Nucleophilic Substitution Using N-Heterocyclic Carbenes and Nickel(Ⅱ) Chloride as Catalysts[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.20527.

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One Pot Continuous Reaction of Benzoin Condensation and Allylic Nucleophilic Substitution Using N-Heterocyclic Carbenes and Nickel(Ⅱ) Chloride as Catalysts

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