Copper Acetate Catalyzed Reduction and N-Formylation of Nitroarenes: A Simple and Inexpensive Approach for Synthesis of Formamide

doi:10.19894/j.issn.1000-0518.200390

Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (12): 1632-1638.DOI: 10.19894/j.issn.1000-0518.200390

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Copper Acetate Catalyzed Reduction and N-Formylation of Nitroarenes: A Simple and Inexpensive Approach for Synthesis of Formamide

ZHANG Hong-Yan¹, YANG Meng-Zhi¹, JIANG Chun-Yong^2*, CAI Xiao-Hua ^1*

¹(School of Chemical Engineering, Guizhou Minzu University, Guiyang 550025, China)
²(School of Ethnic-Minority Medicine, Guizhou Minzu University, Guiyang 550025, China)

Received:2020-12-23 Revised:2021-04-15 Published:2021-12-01 Online:2022-02-01
Supported by:
National Natural Science Foundation of China (No.51863004), the National Science Foundation of the Guizhou Science and Technology Department (No.[2018]1007) and the Innovation and Venture Project of the University Students of Guizhou Province (No.202010672057)

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Abstract

Abstract: Formamide is an important intermediate for the preparation of drugs, dyes, perfumes and other functional chemicals and synthetic reagents, and the development of simple, green and economic strategy for the synthesis of formamides has always attracted extensive attention in the field of synthetic chemistry and industry. In this paper, a copper acetate catalyzed strategy for the formation of formamides through one-pot direct reduction and N-formylation of nitroarenes in a formic acid-ammonium acetate buffer system has been developed. This approach provides a simple and inexpensive strategy access to various formamides with up to 91% yields under optimal conditions. The yield of the product is 77% and there is no loss of the catalyst activity when it is recycled for five times.

Key words: Formamide, N-formylation, Nitroarene, Cu(II)-catalyzed, Formic acid-ammonium acetate buffer system

CLC Number:

O626

ZHANG Hong-Yan, YANG Meng-Zhi, JIANG Chun-Yong, CAI Xiao-Hua. Copper Acetate Catalyzed Reduction and N-Formylation of Nitroarenes: A Simple and Inexpensive Approach for Synthesis of Formamide[J]. Chinese Journal of Applied Chemistry, 2021, 38(12): 1632-1638.

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Copper Acetate Catalyzed Reduction and N-Formylation of Nitroarenes: A Simple and Inexpensive Approach for Synthesis of Formamide

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