Abstract: A new meso-tetra[4-(5-fluorouracil-1-yl acetoxyl)phenyl]porphyrin compound(A) was synthesized from meso-tetra(4-hydroxyphenyl) porphyrin with 5-fluorouracil-1-yl acetic acid by using N,N′-dicyclohexylcarbdiimide as dehydration agent with a yield of 12.7%. The zinc complex(B) of the compound was prepared by the reaction of porphyrin(A) with Zn(OAc)2 with a yield of 30.8%. The structures of the products were characterized by UV-Vis, IR, 1H NMR, MS and elemental analysis.

Key words: porphyrin, zinc porphyrin, 5-fluorouracil, synthesis