Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives

doi:10.3724/SP.J.1095.2011.00496

Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (07): 747-752.DOI: 10.3724/SP.J.1095.2011.00496

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Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives

LI Hongfei^*, ZHANG Liangze, WU Dingming, MU Weining, ZHOU Juntao

(School of Material Science and Engineering,Jiangsu University of Science and Technology,Zhenjiang 212003)

Received:2010-08-25 Revised:2010-10-28 Published:2011-07-10 Online:2011-07-10

Abstract

Abstract:

Using 4,6-dichlorin-5-amino-pyrimidine as a starting material, a serials of 6-chlorin-8-alkyl-9-aryl-purine derivatives have been designed and synthesized via N-alkylation, condensation and chloridization. All synthesized compounds were confirmed by elemental analysis, MS and 1H NMR techniques. The effects of catalyst on N-alkylation, the amounts of polyphosphoric acid(PPA) on condensation, the microwave heating process on chloridization were investigated.

Key words: Purine Derivatives, N-alkylation, condensation, chloridization, Synthesis

CLC Number:

O631

LI Hongfei*, ZHANG Liangze, WU Dingming, MU Weining, ZHOU Juntao. Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives[J]. Chinese Journal of Applied Chemistry, 2011, 28(07): 747-752.

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Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives

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