Synthesis and Anti-tumor Activity of 1-(4-chloro Chloroaniline)-4-(4-pyridylmethyl)- 2,3-Benzodiazine Succinate

doi:10.3724/SP.J.1095.2011.00006

Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (12): 1375-1378.DOI: 10.3724/SP.J.1095.2011.00006

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Synthesis and Anti-tumor Activity of 1-(4-chloro Chloroaniline)-4-(4-pyridylmethyl)- 2,3-Benzodiazine Succinate

CHEN Guanhong, WANG Jianing^*, KONG Xue, LIU Kechun

(Key Laboratory of Applied Microbiology of Shandong Province,Biology Institute of Shandong Academy of Sciences,Jinan 250014)

Received:2011-01-06 Revised:2011-03-21 Published:2011-12-10 Online:2011-12-10

Abstract

Abstract:

1-(4-Chloroaniline)-4-(4-pyridylmethyl)-2,3-benzodiazine succinate(4) was synthesized by addition, rearrangement, substitution and halogenesis steps with phthalide and 4-pyridinecarbaldehydes as starting reagents. The intermediate and target compound 4 were characterized by 1H NMR, MS and HPLC. After purification by recrystallization, the compound 4(98.1% purity estimated by HPLC) was experimentally used to treat colorectal cancer nude mice. The result shows that this compound obviously restrains the growth of tumors.

Key words: chloroaniline(pyridylmethyl)benzodiazine succinate, chemical synthesis, Anti-tumor activity

CLC Number:

O621.3

CHEN Guanhong, WANG Jianing*, KONG Xue, LIU Kechun. Synthesis and Anti-tumor Activity of 1-(4-chloro Chloroaniline)-4-(4-pyridylmethyl)- 2,3-Benzodiazine Succinate[J]. Chinese Journal of Applied Chemistry, 2011, 28(12): 1375-1378.

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Synthesis and Anti-tumor Activity of 1-(4-chloro Chloroaniline)-4-(4-pyridylmethyl)- 2,3-Benzodiazine Succinate

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