Synthesis and Characterization of A New Schiff Base Copper(Ⅱ) Complex from Tris(hydroxymethyl)aminomethane and 2-Pyridinecarboxaldehyde, and Its Interaction with DNA

doi:10.3724/SP.J.1095.2010.90646

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (08): 903-906.DOI: 10.3724/SP.J.1095.2010.90646

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Synthesis and Characterization of A New Schiff Base Copper(Ⅱ) Complex from Tris(hydroxymethyl)aminomethane and 2-Pyridinecarboxaldehyde, and Its Interaction with DNA

YANG Xin-Bin¹*, ZHANG Jin-Sheng², CHEN Zhao-Hui¹, ZENG Ren-Quan¹

(1.Department of Basic Science,Rongchang Campus,Southwest University,Chongqing 402460;
2.School of Chemistry and Material Science,Guizhou Normal University,Guiyang)

Received:2009-10-06 Revised:2009-12-02 Published:2010-08-10 Online:2010-08-10

Abstract

Abstract:

A schiff base copper complex prepared through the condensation between tris(hydroxymethyl)aminomethane and 2-pyridinecarboxaldehyde was characterized by elemental analysis, molar conductance, IR and HRMS. The interaction of the complex with culf thymus(CT-DNA) was investigated by UV spectra, viscosity measurements and DNA thermal denaturation experiments. The experimental results show that the mode of the complex bound to DNA is intercalation.

Key words: Copper complex, CT-DNA, inercalation

CLC Number:

O611.6

YANG Xin-Bin1*, ZHANG Jin-Sheng2, CHEN Zhao-Hui1, ZENG Ren-Quan1. Synthesis and Characterization of A New Schiff Base Copper(Ⅱ) Complex from Tris(hydroxymethyl)aminomethane and 2-Pyridinecarboxaldehyde, and Its Interaction with DNA[J]. Chinese Journal of Applied Chemistry, 2010, 27(08): 903-906.

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Synthesis and Characterization of A New Schiff Base Copper(Ⅱ) Complex from Tris(hydroxymethyl)aminomethane and 2-Pyridinecarboxaldehyde, and Its Interaction with DNA

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