Chinese Journal of Applied Chemistry

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (02): 155-158.DOI: 10.3724/SP.J.1095.2010.90115

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Preparation and Characterization of Crosslinker of Multi-aldehyde Sodium Alginate

WANG Qin-Mei1,2, ZHANG Yi-Xia1, LI Zhuo-Ping1, XU Jia-Qi1, XIE Hui-Lan1, JI Xiao-Li1, TENG Wei3*   

  1. (1.Laboratory of Bioactive Materials,First Affiliated Hospital;
    2.Institute of Cardiology and Angiology;3.Guanghua Stomatological Affiliated Hospital,
    Sun Yat-sen University,Guangzhou 510080)
  • Received:2009-02-23 Revised:2009-05-15 Published:2010-02-10 Online:2010-02-10

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Abstract:

Multiple aldehyde  groups(MASA) was prepared using sodium metaperiodate as an oxidant to oxidize sodium alginate(SA) in the mixed solvents of water and ethyl alcohol. The oxidized sodium alginate was characterized by Fehling′s reagent, electric titration of hydroxylamine hydrochloride-NaOH, Ubbelohde viscometer and the crosslink reaction with gelatin. Results show that the oxidized sodium alginate reacted with Fehling′s reagent in solution to form brick-red precipitate. The oxidation degree increased with the increases of the concentration of sodium metaperiodate and reaction time. The maximum of oxidation degree reached about 80% when the molar ratio of sodium periodate to monomer unit of sodium alginate was 80% and the yield was about 58.7%. The viscosity decreased rapidly with the increases of the concentration of sodium metaperiodate and reaction time. MASA with an oxidation degree of 20%, 40% or 60% gelled gelatin within 5 min at 37 ℃. Thereby, polysaccharide crosslinker of multi-aldehyde sodium alginate with controllable molecular mass and oxidation degree could be prepared in a high yield by adjusting the concentration of sodium metaperiodate and reaction time in a waterethanol medium.

Key words: solium alginate, oxidation, sodium metaperiodate, polysaccharide crosslinker

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