Abstract:

Indomethacin is a nonsteroidal anti-inflammatory drug with pharmacologic effects such as antipyretic and analgesic and anti-inflammatory. However， indomethacin's low water solubility， low bioavailability and its irritation to the gastrointestinal tract have severely limited its clinical application. To address these problems， an indomethacin-loaded core-shell structured nanofiber with biphasic drug release properties was prepared by electrostatic spinning using Eutectic RS100 and polyvinylpyrrolidone （PVP K30） as a slow-release matrix. The parameters of the preparation process optimized by orthogonal design test were voltage 16.94 kV， receiver distance 11.02 cm and flow rate 1.44 mL/h. The diameter of the drug-loaded nanofibers was mostly distributed between 600~800 nm， with an average diameter of （675±177） nm， which had good morphology and coaxial structure， which was conducive to the biphasic release of indomethacin. In vitro release and preliminary pharmacodynamic studies have shown that the drug-loaded nanofibers can be continuously released for about 25 h， and release 50% of the cumulative release in less than 2 h， which has the performance of immediate-release and sustained-release biphasic release， excellent anti-inflammatory and analgesic effects， and can effectively promote wound healing. It is expected that this study can provide a reference for the development of new medical wound dressings.

Key words: Electrostatic spinning, Indomethacin, Sustained release system, Wound dressing, Biphasic drug release