Development in Probes on Outer Surface of Nanochannels for Detecting Biomarkers

doi:10.19894/j.issn.1000-0518.230304

Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (1): 87-99.DOI: 10.19894/j.issn.1000-0518.230304

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Development in Probes on Outer Surface of Nanochannels for Detecting Biomarkers

Li-Zhen YUAN, Ni-Ya LIN, Yun-Fan ZHANG, Jing-Jing HU(), Xiao-Ding LOU, Fan XIA

State Key Laboratory of Biogeology and Environmental Geology，Engineering Research Center of Nano-Geomaterials of Ministry of Education，Faculty of Materials Science and Chemistry，China University of Geosciences，Wuhan 430074，China

Received:2023-10-05 Accepted:2023-12-15 Published:2024-01-01 Online:2024-01-30
Contact: Jing-Jing HU
About author:hujingjing@cug.edu.cn
Supported by:
the National Natural Science Foundation of China(22090050)

Abstract

Abstract:

Biomarkers， such as ions， small molecules， proteins， polysaccharides， nucleic acids， and cells， are involved in the building of organisms and play an important role in the life process. Accurate detection of these biomarkers is of great significance for disease research， early diagnosis， drug evaluation， and human health monitoring. The solid-state nanochannel is modified by functionalizing the outer surface of the nanochannel， which eliminates the restriction on the target molecule and greatly improves the speed and sensitivity of detection by means of a change based on the ion signal. This paper reviews the detection principle of solid-state nanochannels with modified outer surface in biomarkers， summarizes the research progress of solid-state nanochannels modified on outer surfaces in biomarker analysis， and briefly looks forward to the challenges and development opportunities of solid-state nanochannels modified on outer surfaces.

Key words: Nanochannels, Outer surface, Biomarkers

CLC Number:

O654

Li-Zhen YUAN, Ni-Ya LIN, Yun-Fan ZHANG, Jing-Jing HU, Xiao-Ding LOU, Fan XIA. Development in Probes on Outer Surface of Nanochannels for Detecting Biomarkers[J]. Chinese Journal of Applied Chemistry, 2024, 41(1): 87-99.

Figures/Tables 9

Fig.1 The content of this review

Fig.2 （a） Schematic illustration of JNU-3@AAO-based nanofluidic sensor for the detection of Hg（Ⅱ）［24］；（b） Schematic diagram of bio-inspired solid-state nanochannels （DNA@IWHydrophilic+DNA@OSHydrophilic and DNA@IWHydrophilic+None@OSHydrophobic） sensing target［25］

Fig.3 （a） Schematic illustration of JNU-3@AAO-based nanofluidic sensor for the detection of Hg（Ⅱ） and I-V plot of the test results［29］；（b） Schematic diagram of Cu2-x Se/AAO nanochannels for the detection of naproxen［30］；（c） Schematic diagram of CP/AAO solid-state nanochannels for the detection of formaldehyde［31］

Fig.4 （a） Schematic diagram of the principle of thrombin recognition detection［34］；（b） Schematic illustration of the detection of MUC1 based on the Au-AAO ion channel［35］；（c） Schematic illustration of the aptamer-functionalized nanochannels for one-step detection of SARS-CoV-2［36］

Fig.5 （a） Schematic diagram showing the peptide self-assembly on the block layer of PAA for dynamic monitoring of MMP activities at the biomimetic cell/ECM interface［40］；（b） Schematic of the solid-state nanochannel detection of MMP-2 by peptide probe functionalization［41］；（c） Schematic drawing of experimental procedures for the trypsin-PLL cleavage reaction［42］

Fig.6 Schematic representation of POS functionalized nanochannel array used to identify unfolded proteins［43］

Fig.7 Schematic diagram of the principle of PAA membrane surface modification detection of polysaccharides［51］

Fig.8 （a） Illustration of surface modification and miRNA detection on the nanochannel-ionchannel hybrid［54］；（b） Schematic illustration of the RCA process triggered by DNA targets through the T4 polynucleotide kinase reaction illustration of surface modification and miRNA detection on the nanochannel-ionchannel hybrid［57］

Fig.9 （a） Diagrammatical illustration of the CTCs capture and release process on the nanochannel-ion channel hybrid［61］；（b） Schematic demonstration of the CTCs capture and release processes and the corresponding I-V curves of the DAN/AAO hybrid［62］

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Development in Probes on Outer Surface of Nanochannels for Detecting Biomarkers

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