Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (1): 147-155.DOI: 10.19894/j.issn.1000-0518.230234
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Ling-Bo LIU1, Shuang LI1, Kang-Bing WU1,2(
)
Received:2023-08-07
Accepted:2023-10-18
Published:2024-01-01
Online:2024-01-30
Contact:
Kang-Bing WU
About author:kbwu@hust.edu.cnSupported by:CLC Number:
Ling-Bo LIU, Shuang LI, Kang-Bing WU. Laser-Induced Graphene-Based Integrated Arrays for the Determination of Trimetazidine[J]. Chinese Journal of Applied Chemistry, 2024, 41(1): 147-155.
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URL: http://yyhx.ciac.jl.cn/EN/10.19894/j.issn.1000-0518.230234
Fig.1 （A） Design image of the integrated arrays； （B） Process of laser engraving； （C） Integrated arrays after laser engraving； （D） Resistance measurement of integrated arrays； （E） Integrated arrays after encapsulation and coating with Ag/AgCl slurry； （F） Connection between the integrated array and the electrochemical workstation
Fig.2 Raman spectra of PI， LIG-50， LIG-60， LIG-70 and LIG-80
Fig.3 Top-view SEM images of （A， E） LIG-50 array， （B， F） LIG-60 array， （C， G） LIG-70 array and （D， H） LIG-80 array
Fig.4 Sectional-view SEM images of （A） LIG-50 array， （B） LIG-60 array， （C） LIG-70 array and （D） LIG-80 array
Fig.5 CV curves of 5 mmol/L K3［Fe（CN）6］ on （A） LIG-50 array， （B） LIG-60 array， （C） LIG-70 array and （D） LIG-80 array at different scan rates； （E） The plots of Ipa-v1/2 on different arrays； （F） Resistance changes of different arrays with laser power （error bars represent the standard deviation of three measurements）
Fig.6 （A） Nyquist plots of 0.5 mmol/L TMZ on different arrays； Bias voltage： 0.55 V， Frequency range： 0.03~10000 Hz； Inset： the Randles equivalent circuit （Rs， CPE， Rct and Zw represent the solution resistance， constant phase angle element， charge transfer resistance and Warburg impedance）. （B） LSV curves of 10 μmol/L TMZ on different arrays
Fig.7 （A） CV curves of 20 μmol/L TMZ on LIG-70 array at different scan rates， inset： Ipa-v plot； （B） Plot of Epa-ln v； （C） CV curves of 20 μmol/L TMZ in phosphate buffer with different pH values on LIG-70 array at a scan rate of 100 mV/s； （D） Plot of Epa-pH
Fig.8 Effects of （A） pH values， （B） initial potential and （C） accumulation time on the oxidation peak current of 5 μmol/L TMZ； （D） LSV curves of TMZ with different concentrations on LIG-70 array； （E） The calibration curve of TMZ； （F） Response siganls of 5 μmol/L TMZ in the absence and in the presence of interfertants. The error bars represent the standard deviations of three measurements
| Sample | Added/（μmol·L－1） | Total found/（μmol·L－1） （mean±SD） | RSD/% | Recovery/% |
|---|---|---|---|---|
| 1 | 1.00 | 1.01±0.04 | 3.95 | 101.0 |
| 5.00 | 5.16±0.06 | 1.20 | 103.2 | |
| 20.00 | 20.25±0.74 | 3.66 | 101.3 | |
| 2 | 1.00 | 0.96±0.03 | 2.89 | 96.0 |
| 5.00 | 4.81±0.04 | 0.79 | 96.3 | |
| 20.00 | 20.63±0.42 | 2.04 | 103.2 | |
| 3 | 1.00 | 0.96±0.02 | 2.17 | 96.0 |
| 5.00 | 4.85±0.06 | 1.28 | 97.1 | |
| 20.00 | 21.24±0.45 | 2.12 | 106.2 |
Table 1 Determination of TMZ in urine samples from volunteers （n=3）
| Sample | Added/（μmol·L－1） | Total found/（μmol·L－1） （mean±SD） | RSD/% | Recovery/% |
|---|---|---|---|---|
| 1 | 1.00 | 1.01±0.04 | 3.95 | 101.0 |
| 5.00 | 5.16±0.06 | 1.20 | 103.2 | |
| 20.00 | 20.25±0.74 | 3.66 | 101.3 | |
| 2 | 1.00 | 0.96±0.03 | 2.89 | 96.0 |
| 5.00 | 4.81±0.04 | 0.79 | 96.3 | |
| 20.00 | 20.63±0.42 | 2.04 | 103.2 | |
| 3 | 1.00 | 0.96±0.02 | 2.17 | 96.0 |
| 5.00 | 4.85±0.06 | 1.28 | 97.1 | |
| 20.00 | 21.24±0.45 | 2.12 | 106.2 |
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