Research Progress on Mechanism and Application of Biomimetic Mineralization

doi:10.19894/j.issn.1000-0518.210460

Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (1): 74-85.DOI: 10.19894/j.issn.1000-0518.210460

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Research Progress on Mechanism and Application of Biomimetic Mineralization

LI Chun,YU Yan-Hao()

Department of Materials Science and Engineering，Southern University of Science and Technology，Shenzhen 518055，China

Received:2021-09-09 Accepted:2021-10-13 Published:2022-01-01 Online:2022-01-10
Contact: Yan-Hao YU
About author:yuyh@sustech.edu.cn
Supported by:
Shenzhen Science and Technology Program(KQTD20180411143514543)

Abstract

Abstract:

Biological minerals represented by calcium carbonate and calcium phosphate are elsewhere in nature. Through different biomineralization processes， they present a wide variety of structures， morphologies， and functions， constituting various tissues and organs. In the field of artificial material synthesis， biomineralized inorganic or inorganic/organic hybrid materials with special structures and biological functions could be obtained by regulating the nucleation and growth of mineral crystal， such as calcium carbonate and calcium phosphate. This article focuses on recent research progresses on the mechanisms and applications of biomimetic mineralization， including crystallization theories （e.g.， classical and non-classical nucleation theories）， crystallization controlling processes （e.g.， using inorganic ions， organic small molecules， biological macromolecules， organic polymers）， biological applications （e.g.， bone tissue engineering， dental enamel restoration， biomimetic enhancement materials， etc.）. At last， we provide a brief outlook on the future research direction of biomimetic mineralization. This article serves as a reference for the preparation and application of advanced bionic materials.

Key words: Biomimetic mineralization, Calcium carbonate, Calcium phosphate

CLC Number:

O614.2

LI Chun, YU Yan-Hao. Research Progress on Mechanism and Application of Biomimetic Mineralization[J]. Chinese Journal of Applied Chemistry, 2022, 39(1): 74-85.

Figures/Tables 6

Fig.1 Schematic illustration of the size dependence of the energetics of nanoscopic nuclei within the framework of classical nucleation theory［11］

Fig.2 Classical models of crystal growth （gray curve） and non-classical models of crystal growth （black curve）［17］

Fig.3 Control of the activity ratio of calcium/magnesium ions on the morphology of calcium carbonate［40］

Fig.4 （a） Macro/micro morphology of biomimetic synthetic nacre；（b） Comparison of mechanical properties of synthetic nacre， natural nacre， pure aragonite and other materials［48］

Fig.5 （a） Preparation of hydroxyapatite/magnesium composite orthopedic implant material；（b） Evaluation of corrosion resistance by volume of released H2 and pH of SBF solution［60］

Fig.6 （a） Schematic illustration of the preparation process and network microstructure of the PVA/Alg/HAP hybrid macrofiber；（b） Typical tensile stress-strain curves of the artificial macrofiber and different SSF obtained from 1） Euprosthenops sp （Pisauridae）， 2） Cyrtophora citricola （Araneidae）， 3） Latrodectus mactans （Theridiidae）， 4） A. diadematus （Araneidae）， and 5） N. edulis （Tetragnathidae）；（c - e） Photograph of a free-standing hybrid macrofiber net， the as-prepared net can bear a static load of 2.5 kg and an impact load of 500 g free-falling from a height of 1 m［69］

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