Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (11): 1423-1431.DOI: 10.19894/j.issn.1000-0518.200396

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Research Advances of Emerging Materials for the Enrichment of Glycopeptides

HUANG Shi-Qi, ZHANG Qi-Wei, ZHU Tian-Rong, ZHENG Qi*   

  1. Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Institute for Interdisciplinary Research, School of Chemical and Environmental Engineering, Jianghan University, Wuhan 430056, China
  • Received:2020-12-28 Accepted:2021-05-17 Published:2021-11-01 Online:2022-01-01
  • Supported by:
    National Natural Science Foundation of China(No.21976069)

Abstract: Glycosylation is one of the most important post-translational modifications of proteins in organisms, which widely participates in the regulation of various life activities. Since glycosylation plays a key role in biological significances, related research has gradually gained attention in the past two decades. Due to the low relative abundance of glycoproteins in biological samples, complex molecular structure, and poor ionization capacity, it has become a challenging subject in glycoproteomics research on how to perform sample pretreatment efficiently. In addition to the classical hydrophilic interaction materials, several novel ones have also been used for the enrichment of glycopeptide in the past decade. In terms of the material matrix, they can be roughly divided into chitosan, organic framework and functionalized polymer materials, etc. This paper summarizes the characteristics and enrichment effect of emerging materials, and prospects their applications.

Key words: Glycosylation, Sample pretreament, Enrichment

CLC Number: