Research Progress of Droplet Generation and Detection Technology of Microfluidic Chip

doi:10.19894/j.issn.1000-0518.200253

Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (1): 1-10.DOI: 10.19894/j.issn.1000-0518.200253

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Research Progress of Droplet Generation and Detection Technology of Microfluidic Chip

ZHENG Jie^‡, WANG Hong^‡, YAN Yan-Peng, CUI Jian-Guo^*

Chongqing University of Technology, Chongqing 400054, China

Received:2020-08-25 Revised:2020-11-03 Published:2021-01-01 Online:2021-02-01
Supported by:
National Science and Technology Support Program Project (No.2015BAI01B14), Chongqing Higher Education Teaching Reform Research General Project (No.173114), Chongqing University of Technology Graduate Education Quality Course Project Funding (No.yyk2017106) and Chongqing Technology Innovation and Application Demonstration (Social People's Livelihood) General Project (No.cstc2018jscx-msyb0290)

Abstract

Abstract: The microfluidic chip droplet technology is a new technology for manipulating tiny volumes of liquids, which can realize the generation and control of high-throughput microscopic samples, as well as the operation of independent droplets. The dispersed micro-droplet unit can be used as an ideal micro-reactor, showing great application potential in the fields of drug screening, material screening and high value-added micro-particle material synthesis in biomedicine. The droplet microfluidic chip uses the change of the fluid shear force to make the immiscible two-phase fluid generate stable and ordered droplets at its interface. The current generation methods of microdroplets mainly include hydrodynamic methods, pneumatic method, light control method and electric method, etc. Droplet-based microfluidic systems are increasingly used to perform complex multiple reactions, measurements and analyses, and can perform ultra-small volume and ultra-high throughput chemical and biological experiments. For the droplet microfluidic system, the speed, size and content of the droplet will affect the final inspection result. Therefore, the real-time detection of the droplet formation rate and the content of the droplet is very important, and it is most commonly used at present. The droplet detection methods include optical detection technology and electrical sensing detection technology. The two-phase flow droplet generation mechanism and the existing droplet generation technology are discussed and analyzed, and the droplet detection technology is also reviewed.

Key words: Microfluidic chip, Droplet generation, Droplet detection

CLC Number:

O654

ZHENG Jie, WANG Hong, YAN Yan-Peng, CUI Jian-Guo. Research Progress of Droplet Generation and Detection Technology of Microfluidic Chip[J]. Chinese Journal of Applied Chemistry, 2021, 38(1): 1-10.

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Research Progress of Droplet Generation and Detection Technology of Microfluidic Chip

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