Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (12): 1383-1388.DOI: 10.11944/j.issn.1000-0518.2016.12.160363

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Improve the Properties of Resveratrol Solid Dispersions by Combined Polymers

WANG Bingab,HUANG Xiaobina,ZHAO Shanab,ZHANG Jianbinab,LYU Yanab,LYU Guojuna*(),MA Xiaojuna*()   

  1. aDivision of Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,Liaoning 116023,China
    bUniversity of the Chinese Academy of Sciences,Beijing 100864,China
  • Received:2016-09-09 Accepted:2016-10-13 Online:2016-12-05 Published:2016-12-05
  • Contact: LYU Guojun,MA Xiaojun
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21576254)

Abstract:

Resveratrol(Res) binary and ternary solid dispersions solid dispersions with poly(vinylpyrrolidone)(PVP) and hydroxypropylmethylcellulose(HPMC) were prepared by the solvent evaporation. Solid dispersions were characterized by Fourier transform infrared spectroscopy(FTIR), X-ray powder diffraction(XRD) and modulated differential scanning calorimetry(MDSC), and the release profiles were also invested. FTIR results reveal hydrogen bonding formed between Res and polymers. The release profiles of both Res solid dispersions are enhanced. However, XRD and MDSC results show that the miscibility of ternary solid dispersions is better than that of its binary solid dispersions. Under accelerated testing condition(40 ℃, 75%RH(relative humity)) for 3 months, XRD, MDSC and the release profiles indicate that Res ternary solid dispersions are more stable than that of its binary solid dispersions. The release profiles and stability of Res ternary solid dispersions are improved with the addition of HPMC.

Key words: resveratrol, amorphous solid dispersion, hydrogen bonding, dissolution, stability