Preparation and Hemocompatibility of Polyurethane Films Grafted with an Unsaturated Sugar-Based Functional Monomer

doi:10.11944/j.issn.1000-0518.2016.04.150259

Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (4): 412-418.DOI: 10.11944/j.issn.1000-0518.2016.04.150259

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Preparation and Hemocompatibility of Polyurethane Films Grafted with an Unsaturated Sugar-Based Functional Monomer

DU Shanshan,ZHAO Chunyu,CHEN Hao,LUO Shiwen,GAO Mengmeng,XIN Zhirong()

Chemistry and Chemical Engineering,Yantai University,Yantai,Shandong 264005,China

Received:2015-07-22 Accepted:2015-12-17 Published:2016-04-01 Online:2016-04-01
Contact: XIN Zhirong
Supported by:
Supported by the National Natural Science Foundation of China(No.21404088), the Natural Science Foundation of Shandong Province(No.ZR2015EM036)

Abstract

Abstract:

A sugar-based functional monomer containing double bond was synthesized by the reaction of D-glucose, hydroxylethyl acrylate and 1,4-butanediamine. The as-prepared compound was confirmed by Fourier transform infrared spectroscopy(FTIR) and proton nuclear magnetic resonance spectroscopy(¹H NMR). The unsaturated sugar monomer was grafted onto the surface of polyurethane(PU) films by UV-induced grafting polymerization. The surface grafting polymerization was confirmed by FTIR in the attenuated total reflection mode(ATR-FTIR). Water contact angle measurement and platelet adhesion were used to study the hydrophilicity and hemocompatibility of the modified PU films, respectively. It is found that the contact angle of modified PU films decreases from 86° to 45°, and the amount of platelet adhesion is reduced from 14.36×10³ cells/mm² to 2.57×10³ cells/mm². The hydrophilicity of the modified PU films is obviously enhanced and a more hemocompatible interface can be obtained between the film and the biomolecules.

Key words: sugar functional monomer, polyurethane, UV-induced graft polymerization, platelet adhesion

DU Shanshan, ZHAO Chunyu, CHEN Hao, LUO Shiwen, GAO Mengmeng, XIN Zhirong. Preparation and Hemocompatibility of Polyurethane Films Grafted with an Unsaturated Sugar-Based Functional Monomer[J]. Chinese Journal of Applied Chemistry, 2016, 33(4): 412-418.

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Preparation and Hemocompatibility of Polyurethane Films Grafted with an Unsaturated Sugar-Based Functional Monomer

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