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一株红树内生真菌Penicillium sp.(ZZF29#)次级代谢产物分离与鉴定

李尚德1*,魏美燕1,李志华1,佘志刚2,林永成2   

  1. (1.广东医学院药学院 东莞 523808；2.中山大学化学与化学工程学院 广州 510275)
  • 收稿日期:2011-09-28 修回日期:2012-03-06 出版日期:2012-06-10 发布日期:2012-06-10
  • 通讯作者: 李尚德，副教授; Tel/Fax:0769-22896567; E-mail:lishangde@gdmc.edu.cn; 研究方向：天然产物化学
  • 基金资助:
    湛江市科技攻关计划项目(2009C3106011)； 广东医学院面上基金资助项目（M2010002）

Isolation and Structure Elucidation of Secondary Metabolites from Mangrove Endophytic Fungus Penicillium sp. (ZZF29#)

LI Shangde1*, WEI Meiyan1, LI Zhihua1, SHE Zhigang2, LIN Yongcheng2   

  1. (1.School of Pharmacy,Guangdong Medical College,Dongguan 523808,China;
    2.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China)
  • Received:2011-09-28 Revised:2012-03-06 Published:2012-06-10 Online:2012-06-10

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摘要： 首研究了一株药用红树内生真菌Penicillium sp.(ZZF29#)的次级代谢产物。用硅胶柱层析、制备薄层层析和重结晶等方法，从该菌发酵液的乙酸乙酯相中分离获得8种单体化合物，运用现代波谱技术并与文献数据对照，鉴定其结构分别为：环(苯丙-丙)二肽(1)、环(苯丙-甘)二肽(2)、环(苯丙-苯丙)二肽(3)、环(苯丙-酪)二肽(4)、大黄素(5)、大黄素甲醚(6)、麦角甾醇(7)和过氧化麦角甾醇(8)。

关键词: 红树内生真菌, 次级代谢产物, 环二肽, 蒽醌, 甾醇

Abstract: The secondary metabolites of the medicinal mangrove endophytic fungus Penicillium sp.(ZZF29#) were firstly studied. Eight compounds were isolated from the ethyl acetate extract of the fermentation using silica gel column chromatography, preparative thin-layer chromatography and recrystallization. The structures of the compounds were identified as cyclo-(Phe-Ala)(1), cyclo-(Phe-Gly)(2), cyclo-(Phe-Phe)(3), cyclo-(Phe-Tyr)(4), emodin(5), physcion(6), ergosterol(7) and peroxide ergosterol(8), by comprehensive spectroscopic characterizations as well as comparison with reported data.

Key words: mangrove endophytic fungus, secondary metabolites, isolation and elucidation, cyclodipeptides, anthraquinones, sterols

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