中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (3): 39-42.

• 研究论文 • 上一篇    下一篇

镧与氨荒乙酸钴多核配合物的合成及抗癌活性

王学智1, 张继民1, 秦红桂2   

  1. 1. 安徽机电学院生物化学工程系 芜湖241000;
    2. 皖南医学院附属弋矶山医院 芜湖
  • 收稿日期:1997-11-24 修回日期:1998-03-20 出版日期:1998-06-10 发布日期:1998-06-10

Synthesis, Characterization and Antitumor Activity of Polynuclear Solid Complex of Lanthanum with Dithiocarbaminoacetic Cobalt

Wang Xuezhi1, Zhang Jimin1, Qin Honggui2   

  1. 1. Department of Biochemical Engineering, Anhui Institute of Mechanical and Electrical Engineering, Wuhu 241000;
    2. Department of Inspection, Yijishan Hospital of Wannan Medical College, Wuhu
  • Received:1997-11-24 Revised:1998-03-20 Published:1998-06-10 Online:1998-06-10

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摘要： 在微波辐射下用低温固相配位反应合成出多核配合物。通过元素分析确定配合物组成为La2(CoL2)3(L=-S2CNHCH2CO2-),并研究了该配合物的摩尔电导、红外光谱、紫外光谱和核磁共振氢谱。配合物的抗癌活性测定结果表明Co(HL)2和La2(CoL2)3有一定的抗癌活性；La2(CoL2)3对肝癌细胞生长有显着抑制作用,对正常肝细胞的生长无影响。

关键词: 镧, 氨荒乙酸钴, 多核配合物, 抗癌活性

Abstract: The new polynuclear solid complex of lanthanum(La) with dithiocarbaminoacetic cobalt [Co(HL)2](L=-S2CNHCH2CO2-) was synthesized in microwave oven at 60 ℃. The product was characterized by elemental analysis, IR spectrum, UV absorption spectrum,1H NMR and molar conductance measurements. The results showed that the composition of the complex was La2(CoL2)3. The preliminary bioassay showed that the complex could significantly inhibit the growth of liver cancer cell, but not affect on the growth of human liver cells.

Key words: lanthanum, dithiocarbaminoacetic cobalt, polynuclear complex, antitumor activity

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