中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (1): 110-112.

• 研究论文 • 上一篇    下一篇

离子表面活性剂胶团对阿斯匹林碱水解反应的影响

史振民, 刘生昆, 张祝莲, 巩育军   

  1. 延安大学化学系 延安 716000
  • 收稿日期:1996-05-04 修回日期:1996-08-12 出版日期:1997-02-10 发布日期:1997-02-10

Inhibition of Basic Hydrolysis Reaction of Aspirin by Micelles of Ionic Surfactants

Shi Zhenmin, Liu Shengkun, Zhang Zhulian, Gong Yujun   

  1. Department of Chemistry, Yanan University, Yanan 716000
  • Received:1996-05-04 Revised:1996-08-12 Published:1997-02-10 Online:1997-02-10

PDF

365

被引次数

5 | 2

摘要： 阿斯匹林(ASP),学名为乙酰水杨酸,有较高的药用价值,还能抗衰老.由于易水解,给生产、调配、使用和贮存带来许多问题,而引起人们的注意[1,2],但研究抑制ASP水解的报道很少[3].本文选用溴化十六烷基三甲基胺(CTAB)和十二烷基硫酸钠(SDS)为表面活性剂,运用分光光度法,分别测定CTAB胶团及其与SDS形成的混合胶团对ASP碱水解反应的影响。

关键词: 表面活性剂, 阿斯匹林, 碱水解反应, 胶团, 抑制作用

Abstract: Cetyltrimethylammonium bromide(CTAB)and sodium dodecyl sulfate(SDS)were used as surfactants and effects of micelles on the basic hydrolysis of aspirin(ASP)were studied spectrophotometrically. When the concentrations of CTABare larger than 7.3?10-3 mol/L, there is an inhibition of basic hydrolysis of ASP, the best concentration being 3.25?10-3 mol/L. At a constant concentration of CTAB, the addition of a small amount of SDScauses the inhibition of CTABto decrease, indicating that SDStakes part together with CTABin the formation of mixed micelles.

Key words: surfactant, aspirin, basic hydrolysis, micelle, inhibition

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