应用化学 ›› 1996, Vol. 0 ›› Issue (1): 109-111.

• 研究简报 • 上一篇    下一篇

铁(Ⅲ)核苷酸配位化合物与转铁蛋白的相互作用

王继波, 赵辉, 孙衍增   

  1. 青岛医学院化学教研室 青岛 266012
  • 收稿日期:1995-07-04 修回日期:1995-09-27 出版日期:1996-02-10 发布日期:1996-02-10

The Interaction Between Ferric Nucleotide Coordination Compounds and Transferrin

Wang Jipo, Zhao Hui, Sun Yianzheng   

  1. Qingdao Medical College, Qingdao 266012
  • Received:1995-07-04 Revised:1995-09-27 Published:1996-02-10 Online:1996-02-10

摘要: 转铁蛋白广泛存在于人体细胞及体液中[1-5],有许多关于铁在小分子配体与转铁蛋白之间交换的研究[6-7],但铁(Ⅲ)核苷酸配合物与转铁蛋白相互作用的研究未见报道.

关键词: 转铁蛋白, 核苷酸, 动力学

Abstract: We have studied the kinetics of interaction between ferric nucleotide coordination compounds and transferrin with spectrophotometry. Results showed that the exchange rate of ferric ion is Fe(Ⅲ)PYR>Fe(Ⅲ)ATP>Fe(Ⅲ)ADP>Fe(Ⅲ)AMP.The exchange reactions between Fe(Ⅲ)ATP,Fe(Ⅲ)ADP or Fe(Ⅲ)PYR and deferrization transferrin are second order reactions, but the reaction mechanism of Fe(Ⅲ) ATP and Fe(Ⅲ) PYR is different from that of Fe(Ⅲ)ADP.The exchange reaction of Fe(Ⅲ) AMP is a first order reaction.

Key words: transferrin, nucleotide, kinetics