中华医学超声杂志

应用化学 ›› 1994, Vol. 0 ›› Issue (5): 79-82.

• 研究论文 • 上一篇    下一篇

2－芳酰氨基－5－[1－苯基－2－羟基－2－(对甲氧基苯)乙基]－1,3,4－噻二唑的合成

冯小明1, 蒋耀忠1, 陈荣2, 明离果2   

  1. 1. 中国科学院成都有机化学研究所 成都 610015;
    2. 西南师范大学化学系 重庆
  • 收稿日期:1994-01-31 修回日期:1994-03-23 出版日期:1994-10-10 发布日期:1994-10-10

Synthesis of 2-Afoylamino-5-(1-phenyl-2-hydroxyanisethyl)-1,3,4-thiadiazoles

Feng Xiaoming1, Jiang Yaozhong1, Chen Rong2, Ming Liguo2   

  1. 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610015;
    2. Department of CChemistry, Southwest Normal University, Chongqing
  • Received:1994-01-31 Revised:1994-03-23 Published:1994-10-10 Online:1994-10-10

PDF

373

被引次数

1

摘要： 2-芳酰氨基-5-苄基-1,3,4-噻二唑1上5-位苄基在EtONa/EtOH中生成负离子,再与对甲氧基苯甲醛亲核加成合成了一系列新的2-芳酰氨基-5-[1-苯基-2-羟基-2-(对甲氧基苯)乙基]-1.3,4-噻二唑2.化合物2的结构经元素分析,IR,1H NMR和MS分析确证。初步观察了2抗菌活性。

关键词: 噻二唑, 亲核加成, 抗菌活性

Abstract: Thirteen title compounds (2) were obtained by nucleophilic addition of benzyl carbanion of 2-aroylamino-5-benzyl-1,3,4-thiadiazoles(1) with anisaldehyde in EtONa/EtOH solution. The structures of the compounds 2 were confirmed by elemental analysis, IR,1H NMR,and MS. The compounds were found to have some fungicidal activity.

Key words: thiadiazole, nucleophilic addition, fungicidal activity

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