应用化学 ›› 2011, Vol. 28 ›› Issue (04): 438-442.DOI: 10.3724/SP.J.1095.2011.00343

• 研究论文 • 上一篇    下一篇

紫杉醇在二甲基亚砜中的溶解行为

赵微微1,2,董叶叶2,李宗孝2*   

  1. (1.西北农林科技大学理学院 杨凌;2.宝鸡文理学院化学化工系 宝鸡  721013)
  • 收稿日期:2010-06-17 修回日期:2010-10-27 出版日期:2011-04-10 发布日期:2011-04-10
  • 通讯作者: 李宗孝,教授; Tel:0917-3566588; E-mail:mingtian8001@163.com; 研究方向:微热量热法对药物特性的研究
  • 基金资助:
    陕西省重点实验室重点科研项目(09JZ066),陕西省计划项目(2006K16-G16)

Dissolution Properties of Paclitaxel in Dimethylsulfoxide

ZHAO Weiwei1,2, DONG Yeye2, LI Zongxiao2*   

  1. (1.College of Science,Northwest A&F University,Yangling;
    2.Department of Chemistry and Chemical Engineering,Baoji University of Liberal Arts and Science,Baoji 721013)
  • Received:2010-06-17 Revised:2010-10-27 Published:2011-04-10 Online:2011-04-10

摘要:

用微热量热仪测量紫杉醇在二甲亚砜中的溶解焓。 得到了微分溶解热(ΔdifHm)和积分溶解热(ΔsolHm),建立了热量与溶质的量之间的关系式。 并得到了紫杉醇在二甲亚砜中溶解过程的动力学方程:da/dt=2.92×10-4×(1-a)1.00,半衰期t1/2=50.43 min,ΔsolHm=32.67 kJ/mol以及ΔsolSm=-204.93 J/(mol·K)。结果表明,利用微热量热法可以为药物半衰期的测定提供一种简便的方法,并可为紫杉醇的临床应用提供理论参考。

关键词: 热力学, 动力学, 溶解热, 紫杉醇, 二甲亚砜

Abstract:

The enthalpies of dissolution of paclitaxel in dimethylsulfoxide(DMSO) was reported. The differential enthalpy(ΔdifHm) and the molar enthalpy(ΔsolHm) were determined, and the relationship between the amount of heat released and the amount of solute was also established. The corresponding kinetic equation that describes the dissolution process is da/dt=2.92×10-4×(1-a)1.00, and the kinetic parameters are obtained as follows:t1/2=50.43 min, ΔsolHm=32.67 kJ/mol, and ΔsolSm=-204.93 J/(mol·K). The result not only provides a simple method for the determination of the half-life for drugs, but it can also offer a theoretical reference for the clinical application of paclitaxel using microcalorimeter.

Key words: thermodynamics, kinetics, dissolution heat, paclitaxel, dimethylsulfoxide

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