中华医学超声杂志

应用化学 ›› 2009, Vol. 26 ›› Issue (12): 1391-1394.

• 研究论文 • 上一篇    下一篇

W/0乳化法制备明胶/β-磷酸三钙多孔复合微球及其物化性能表征

郭燕川1,孙瑞雪1,马铭1,陈丽娟1*,宋宇2,邓旭明2   

  1. (1.中国科学院理化技术研究所 北京 100190;2.吉林大学畜牧兽医学院 长春)
  • 收稿日期:2008-11-20 修回日期:2009-04-15 出版日期:2009-12-10 发布日期:2009-12-10
  • 通讯作者: 陈丽娟，女，研究员; E-mail:chenlijuan@mail.ipc.ac.cn; 研究方向：明胶生产新工艺及其应用
  • 基金资助:
    国家高技术研究发展计划（“八六三”计划，2006AA03Z328）

The preparation and characterization of gelatin/β-tricalcium phosphate porous composite spheres by W/O emulsion process

GUO Yan-Chuan1, SUN Rui-Xue1, MA Ming1, CHEN Li-Juan1*, SONG Yu2, DENG Xu-Ming2   

  1. (1.Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190;
    2.College of Animal Science and Veterinary Medicine,Jilin University,Changchun)
  • Received:2008-11-20 Revised:2009-04-15 Published:2009-12-10 Online:2009-12-10

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摘要：

采用乳液、离子缔合法制备得到明胶（Gel）/β-纳米磷酸三钙(β-TCP)复合多孔微球，其尺寸可通过控制反应的搅拌速度进行调节。 SEM和光学显微镜观察表明，明胶/β-TCP复合微球尺寸在20～40 μm之间，被包敷的磷酸三钙为200 nm左右，微球内部呈多孔结构。 当m（磷酸三钙）∶m（明胶）＞0.4∶1时，有大量花瓣状晶体附着于复合微球的表面，是磷酸三钙溶解和明胶分子诱导重结晶所致。 XRD与IR图谱表明，磷酸三钙纳米粒子与明胶之间存在化学键合，明胶/β-纳米磷酸三钙复合微球的微观结构与自然骨相似。 DSC-TGA结果显示，90%的TCP在乳化过程中与明胶复合。 本文所制备的复合微球，为添加各种药物和促骨生长因子并实现缓释提供了优良的载体。

关键词: 明胶, 磷酸三钙, 乳化

Abstract:

Through W/O emulsion process and ion association method, Gelatin/β-tricalcium phosphate porous composite spheres were fabricated. The size of the composite spheres was controlled by adjusting the rate of stirring. From the SEM image, can it be seen that the size of the composite spheres was arranged from 5um to 30um, and the TCP embedded is about 200nm. When the amount of the TCP added to the composite is up to 0.4:1, a large quantities of petal-like crystal were formed on the surface of the composite spheres. It was assumed that shaped crystal was formed by TCP dissolved in the reactive solution and inductive recrystallization by gelatin molecule. IR and XRD spectrum showed these composite spheres containing the similar structure with the natural bone and the chemical bond existed between the gelatin and TCP. DSC-TGA image illustrated the 90% TCP was embedded inside the gelatin spheres through the emulsion process and strong interaction appeared between them.

Key words: gelatin, β-tricalcium phosphate, emulsion

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