中华医学超声杂志

应用化学 ›› 2020, Vol. 37 ›› Issue (6): 0-.

• 封面图片 •    下一篇

pH可逆激活型不对称菁光敏剂的光动力杀菌活性

赵凯超a,赵旭bcd*(),严秀平bcd*()   

  1. a江南大学 化学与材料工程学院 江苏 无锡 214122
    b江南大学 食品学院,分析食品安全学研究所 江苏 无锡 214122
    c江南大学 食品科学与技术国家重点实验室 江苏 无锡 214122
    d江南大学 国际食品安全联合实验室 江苏 无锡 214122
  • 收稿日期:2020-03-27 出版日期:2020-06-01 发布日期:2020-07-09
  • 通讯作者: 赵旭,严秀平
  • 基金资助:
    国家自然科学基金(21804056)、江苏省自然科学基金(BK20180581)、博士后科学基金(2018M630511)和中央高校基础研究经费(JUSRP51714B,JUSRP11846)资助

pH Reversibly Activated Asymmetric Cyanine Photosensitizer for Photodynamic Antibacterial

ZHAO Kaichaoa,ZHAO Xubcd*(),YAN Xiupingbcd*()   

  1. aSchool of Chemical and Material Engineering,Wuxi,Jiangsu 214122,China
    bInstitute of Analytical Food Safety, School of Food Science and Technology,Wuxi,Jiangsu 214122,China
    cState Key Laboratory of Food Science and Technology,Wuxi,Jiangsu 214122,China
    dInternational Joint Laboratory on Food Safety,Jiangnan University,Wuxi,Jiangsu 214122,China
  • Received:2020-03-27 Published:2020-06-01 Online:2020-07-09
  • Contact: ZHAO Xu,YAN Xiuping
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21804056), the Natural Science Foundation of Jiangsu Province, China(No.BK20180581), China Postdoctoral Science Foundation(No.2018M630511), and the Fundamental Research Funds for the Central Universities(No.JUSRP11846, No.JUSRP51714B)

摘要：

研究了一种pH可逆激活型不对称菁(Acy)的光动力杀菌性能。 结果表明,Acy在细菌所处弱酸性微环境和808 nm激光照射下可特异性激活产生单线态氧,对大肠杆菌和金黄色葡萄球菌均展现出了很好的光动力杀菌效果,而在正常体液条件下无明显的抗菌作用。 这种可特异性激活的光动力特性使得Acy避免了传统光敏剂因缺乏细菌特应性而产生的非特异性损伤,在细菌感染的特异性治疗方面展现出了良好的应用前景。

关键词: pH可逆激活, 光动力杀菌, 近红外, 不对称菁

Abstract:

The photodynamic bactericidal performance of a reversibly activated asymmetric cyanine (Acy) was studied. The results show that Acy can be specifically activated to produce singlet oxygen in the weakly acidic microenvironment of bacteria under the irradiation of 808 nm laser, and shows excellent photodynamic bactericidal effect on both E.coli and S.aureus, but has no photodynamic antibacterial effect under normal physiological condition. The specifically activated photodynamic feature of Acy effectively overcomes the shortcoming of non-specific damage to normal tissues in previous “always on” photosensitizers, making Acy promising for specific antibacteria.

Key words: pH reversible activation, photodynamic antibacteria, near infrared, asymmetric cyanine

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