6种多金属氧酸盐的抑菌作用

doi:10.11944/j.issn.1000-0518.2017.06.160370

摘要/Abstract

摘要：

合成了5种过渡金属取代的Keggin型多金属氧酸盐(Na₇PMo₁₁M(Ⅱ)O₄₀(M=Mn,Fe,Zn,Co,Ni)(简写为PMo₁₁M(Ⅱ)),并通过紫外可见分光光度计和傅里叶变换红外光谱仪对其结构进行了表征。进而运用牛津杯法研究了这5种过渡金属取代的Keggin型多金属氧酸盐和母体H₃PMo₁₂O₄₀(简写为PMo₁₂)对藤黄八叠球菌、金黄色葡萄球菌、枯草芽孢杆菌和大肠杆菌的抑菌活性,并用微量肉汤二倍稀释法测得了这些(共6种)化合物对上述4种菌的最小抑菌浓度(MIC值)和最小杀菌浓度(MBC值)。结果表明,这6种化合物对4种菌均有不同程度的抑制作用,并且对2种球菌的抑制效果优于对2种杆菌的抑制效果。其中(Na₇PMo₁₁M(Ⅱ)O₄₀(M=Ni,Mn,Zn)对4种菌的抑制效果优于其它3种化合物。综合考虑,本研究能够为多金属氧酸盐用于果蔬的防腐保鲜提供更多的理论和实验支持。

关键词: 多金属氧酸盐, 抑菌活性, 牛津杯法

Abstract:

In this study, we synthesised five kinds of Keggin-type transition metal substituted polyoxometalates(Na₇PMo₁₁M(Ⅱ)O₄₀(M=Mn,Fe,Zn,Co,Ni), abbreviated as PMo₁₁M(Ⅱ)(M=Mn,Fe,Zn,Co,Ni)). The structures of these compounds were characterized by UV-visible absorption spectrum and Fourier transform infrared spectrometer(FTIR). And then the antibacterial activities of the five kinds of Keggin-type transition metal substituted polyoxometalates(PMo₁₁M(Ⅱ)(M=Mn,Fe,Zn,Co,Ni) and their parent H₃PMo₁₂O₄₀(abbreviated PMo₁₂) on Sarcina lutea(S.lutea), Staphylococcus aureus(S.aureus), Bacillus subtilis(B.subtilis) and Escherichia coli(E.coli) were investigated by Oxford plate. Also, the minimum inhibitory concentration(MIC) and the minimum bactericidal concentration(MBC) were tested by broth microdilution methods. The results show that the six kinds of polyoxometalates can inhibit the proliferation of these four different kinds of bacteria to different extents, and the antimicrobial activities of all compounds on S.lutea and S.aureus are more effective than those against B.Subtilis and E.coli. Among these compounds, the antibacterial activities of (PMo₁₁M(Ⅱ)(M=Ni,Mn,Zn)) were superior to the other three compounds. This study will provide more theoretical and experimental supports for polyoxometalates as preservative agents in fruit and vegetables.

Key words: polyoxometalates, antibacterial activities, oxford plate

谢乐芳, 邢蕊, 王芳, 王力. 6种多金属氧酸盐的抑菌作用[J]. 应用化学, 2017, 34(6): 700-704.

XIE Lefang, XING Rui, WANG Fang, WANG Li. Antibacterial Activities of Six Kinds of Polyoxometalates[J]. Chinese Journal of Applied Chemistry, 2017, 34(6): 700-704.

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