烟酰胺腺嘌呤二核苷酸(NAD+)类似物的合成及性质

doi:10.11944/j.issn.1000-0518.2016.05.150412

摘要/Abstract

摘要：

合成了3种新型结构稳定的烟酰胺腺嘌呤二核苷酸(NAD⁺)类似物并通过¹H NMR、¹³C NMR、³¹P NMR和HRMS进行了表征。 NAD⁺类似物经80 ℃加热24 h后,通过¹H NMR确认其结构稳定;通过循环伏安法(CV)测定了其电化学性质,表明其仍然具有良好的氧化还原性能。

关键词: 烟酰胺腺嘌呤二核苷酸, 类似物, 氧化还原活性

Abstract:

Three novel stable nicotinamide adenine dinucleotide(NAD⁺) analogs were synthesized and characterized by ¹H NMR, ¹³C NMR, ³¹P NMR and HRMS. The NAD⁺ analogs show good stability after heating at 80 ℃ for 24 h. Cyclic voltammetry(CV) measurement of the electrochemical properties of NAD⁺ analogs shows that they remain good redox activities.

Key words: nicotinamide adenine dinucleotide, analogs, redox activity

侯淑华, 曲忠国, 钟克利, 边延江, 汤立军. 烟酰胺腺嘌呤二核苷酸(NAD⁺)类似物的合成及性质[J]. 应用化学, 2016, 33(5): 549-553.

HOU Shuhua, QU Zhongguo, ZHONG Keli, BIAN Yanjiang, TANG Lijun. Synthesis and Properties of Novel Nicotinamide Adenine Dinucluotide (NAD⁺) Analogs[J]. Chinese Journal of Applied Chemistry, 2016, 33(5): 549-553.

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