离子液体中聚乙二醇维生素E琥珀酸酯的合成

doi:10.11944/j.issn.1000-0518.2015.06.140366

摘要/Abstract

摘要：

以离子液体为催化剂,由维生素E经两步酯化反应合成了聚乙二醇1000(PEG1000)维生素E琥珀酸酯。以离子液体1-(N',N'-二甲胺乙基)-3-甲基咪唑四氟硼酸盐为催化剂、1,2-二氯乙烷为助溶剂、维生素E与琥珀酸酐摩尔比为1:1.2,在80 ℃条件下反应4 h,维生素E琥珀酸酯(TAS)的产率为90%。以1-丙磺酸基-3-甲基咪唑硫酸氢盐/甲苯为反应体系,TAS与PEG1000摩尔比为1:2,在100 ℃下反应5 h,PEG1000维生素E琥珀酸酯(TPGS)收率为91%。

关键词: 离子液体, 绿色催化, 维生素E琥珀酸酯, 聚乙二醇1000维生素E琥珀酸酯

Abstract:

Polyethylene glycol 1000(PEG 1000) Vitamin E succinate was prepared by a two-step esterification reaction of Vitamin E using ionic liquids as reaction catalysts. Vitamin E succinate(TAS) was obtained via the esterification of vitamin E catalyzed by 1-(N',N'-dimethylamino-ethyl)-3-methyl-imidazolium tetrafluoroborate. Under the conditions of 1:1.2 molar ratio of Vitamin E and succinic anhydride in 1,2-dichloroethane at 80 ℃ for 4 h, the isolated yield reached 90%. Under 1:2 molar ratio of TAS and PEG 1000 for 5 h at 100 ℃, polyethylene glycol 1000 Vitamin E succinate was synthesized in 1-methyl-3-propyl sulfonic acid imidazolium hydrogen sulfate/toluene media with 91% yield.

Key words: ionic liquid, green catalysis, vitamin E succinate, polyethylene glycol 1000 vitamin E succinate

中图分类号:

巩凯, 王理国, 陈敬华. 离子液体中聚乙二醇维生素E琥珀酸酯的合成[J]. 应用化学, 2015, 32(6): 652-657.

GONG Kai, WANG Liguo, CHEN Jinghua. Synthesis of Polyethylene Glycol Vitamin E Succinate in Ionic Liquid[J]. Chinese Journal of Applied Chemistry, 2015, 32(6): 652-657.

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