壳聚糖-聚丙烯酸复合水凝胶的药物控制释放行为

doi:10.3724/SP.J.1095.2014.30659

摘要/Abstract

摘要： 以壳聚糖(Cs)和丙烯酸(AA)为原料，利用自由基聚合法制备了具有孔洞结构的复合水凝胶Cs-PAA，并研究了AA的量、交联剂的量、聚合温度和AA的中和度对水凝胶溶胀度的影响以及复合水凝胶对烟酸的控制释放。结果表明，Cs-PAA复合水凝胶具有良好的pH值、离子强度敏感性，且溶胀度最高达1228 g/g，其在pH=686的缓冲溶液中的烟酸累积释放率明显大于其在pH=1.80的缓冲溶液，因此Cs-PAA水凝胶可作为肠口服药物的载体。

关键词: 复合水凝胶, 溶胀度, 药物释放, 烟酸

Abstract: The chitosan(Cs) and acrylic acid(AA) were used to prepare the composite hydrogel(Cs-PAA) by radical polymerization method. The influences of reaction temperature, neutralization degree of acrylic acid, amounts of cross-linking agent and acrylic acid on the swelling degree of the composite hydrogels were investigated. In addition, the controlled release behaviors of prepared hydrogels for niacin were evaluated. The swelling degree of prepared hydrogels is up to 1228 g/g. It exhibits excellent pH and ionic strength sensitivity. The cumulative release rate in a pH=6.86 buffer solution is significantly higher than that in a pH=1.8 buffer solution. Therefore, the hydrogels can be used as carriers of intestinal oral drugs.

Key words: composite hydrogel, swelling degree, drug release, niacin

中图分类号:

O646.9

杨晓慈, 任杰, 姚萌奇, 张晓燕, 杨武. 壳聚糖-聚丙烯酸复合水凝胶的药物控制释放行为[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30659.

YANG Xiaoci, REN Jie*, YAO Mengqi, ZHANG Xiaoyan, YANG Wu. Controlled Drug Release Behaviors of Chitosan-Poly(acrylic acid) Composite Hydrogels[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30659.

参考文献

[1] Zhao Y,Kang J,Tan T W. Salt-, pH- and Temperature-responsive Semi-interpenetrating Polymer Network Hydrogel Based on Poly(aspartic acid) and Poly(acrylic acid)[J]. Polymer,2006,47(22):7702-7710.

[2] JIANG Lei,LIN Baofeng,LIANG Xingquan,et al. Progress in the Research of Hydrogels of Chitosan and Its Derivatives[J]. Chemistry,2007,(1):47-51(in Chinese).

江磊,林宝凤,梁兴泉,等. 壳聚糖及其衍生物水凝胶的研究进展[J]. 化学通报,2007,(1):47-51.

[3] Ramesh N,Chandru K,Sekaran S,et al. A Novel Injectable Temperature-sensitive Zinc Doped Chitosan/β-glycerophosphate Hydrogel for Bone Tissue Engineering[J]. Int J Biol Macromol,2013,54:24-29.

[4] Ding P,Huang K L,Li G Y,et al. Preparation and Properties of Modified Chitosan as Potential Matrix Materials for Drug Sustained-release Beads[J]. Int J Biol Macromol,2007,41:125-131.

[5] Li G Y,Guo L,Chang X J,et al. Thermo-sensitive Chitosan Based Semi-IPN Hydrogels for High Loading and Sustained Release of Anionic Drugs[J]. Int J Biol Macromol,2012,50:899-904.

[6] CHEN Shilan,LIU Mingzhu,LV Shaoyu,et al. Preparation and Drug Release Behavior of Chitosan Grafted Poly(methacrylic acid) Gel Bead[J]. Chinese J Appl Chem,2013,30(3):252-259(in Chinese).

陈世兰,柳明珠,吕少瑜,等. 壳聚糖-g-聚甲基丙烯酸凝胶粒的制备及其药物释放行为[J]. 应用化学,2013,30(3):252-259.

[7] HE Qiangfang,LI Guoming,WU Haizhen,et al. Preparation and Drug Releasing Property of 5-Fluorouracil Loaded Chitosan Microsphere[J]. Chinese J Appl Chem,2004,21(2):192-195(in Chinese).

何强芳,李国明,巫海珍,等. 5-氟尿嘧啶壳聚糖微球的制备及其释药性能[J]. 应用化学,2004,21(2):192-195.

[8] WEI Qingbo，BAI Zhiyang，JIANG Yua. Preparation and Characterization of P(AAm-co-AA)/Ag Composite Materials[J]. Appl Chem Ind,2013,42(1):62-65(in Chinese).

魏清渤,白志洋,江源. P(AAm-co-AA)/Ag复合材料制备及表征[J]. 应用化工,2013,42(1):62-65.

[9] DONG Zhengfeng，HE Peixin，ZHANG Yuhong，et al. Study on Synthesis and Swelling Behavior of Poly(AA-AMPS) Hydrogel[J]. Adhesion,2012,10:50-53 (in Chinese).

董正凤,何培新,张玉红,等. P(AM-AMPS)水凝胶的制备与性能研究[J]. 粘接,2012,10:50-53.

[10] Florypj. Principles of Polymer Chemistry[M]. Ithaca,NY:Cornell University Press,1953.

[11] Rodríguez R,Alvarez-Lorenzo C,Concheiro A. Cationic Cellulose Hydrogels:Kinetics of the Cross-linking Process and Characterization as pH-/Ion-sensitive Drug Delivery Systems[J]. J Controll Release,2003,86(2/3):253-265.

[12] TAN Guoxin,RUAN Xiongjie,NING Chengyun,et al. Study on Controlled Drug Release Properties of PEGDA/NIPAM Copolymer Hydrogels[J]. Ion Exch Adsorpt,2010,26(6):497-502(in Chinese).

谭帼馨,阮雄杰,宁成云,等. PEGDA/NIPAM共聚物水凝胶的药物释放性能研究[J]. 离子交换与吸附,2010,26(6):497-502.

[13] Yu C Y,Zhang X C,Zhou F Z,et al. Sustained Release of Antineoplastic Drugs from Chitosan-reinforced Alginate Microparticle Drug Delivery Systems[J]. Int J Pharm,2008,357:15-21.

[1]	黄旭娟, 王婷, 丁正青, 杨欣欣, 蔡照胜, 商士斌. 脱氢枞氧基聚氧乙烯缩水甘油醚接枝羟乙基壳聚糖水凝胶制备及其性能[J]. 应用化学, 2022, 39(9): 1421-1428.
[2]	弓韬, 文朝朝, 秦凯莉, 赵莹珠, 张宇奇, 梁文婷, 董川. 甲酰基去氧胆酸修饰的Fe₃O₄纳米粒子的制备及其对土霉素负载的应用[J]. 应用化学, 2022, 39(12): 1920-1926.
[3]	张继东,李家源,金华峰. 基于荧光效应的小分子抗癌药物释放体系研究进展[J]. 应用化学, 2019, 36(7): 733-748.
[4]	梁学称,邓裕坤,裴小朋,翟侃侃,徐昆,谭颖,王丕新. 非冻结水对微球复合水凝胶机械性能的影响[J]. 应用化学, 2018, 35(11): 1301-1308.
[5]	李鹏翀, 徐昆, 谭颖, 王丕新. 微凝胶增强两性复合水凝胶的制备与性能[J]. 应用化学, 2015, 32(4): 386-391.
[6]	邓新旺, 胡惠媛, 罗仲宽, 吴茂盛, 周莉. 肝素钠/聚乙烯醇复合水凝胶的制备与性能[J]. 应用化学, 2015, 32(12): 1358-1363.
[7]	李冠君, 贾春梅, 袁文兵. 烟酸与氧化锌或碱式碳酸锌的机械化学反应[J]. 应用化学, 2013, 30(11): 1372-1374.
[8]	陈世兰, 柳明珠, 吕少瑜, 金淑萍, 陈勇. 壳聚糖-g-聚甲基丙烯酸凝胶粒的制备及其药物释放行为[J]. 应用化学, 2013, 30(03): 252-259.
[9]	盘登科, 张慧, 牟元华. 药物磁靶向定位释放模拟装置的设计与应用[J]. 应用化学, 2012, 29(01): 69-74.
[10]	黄琼瑜,张明霞,刘芳,肖秀峰,刘榕芳. 壳聚糖/聚乙烯醇/三聚磷酸钠三元复合微球的制备及表征[J]. 应用化学, 2010, 27(01): 21-26.
[11]	石文兵. 逆胶束介导化学发光法测定烟酸占替诺[J]. 应用化学, 2008, 25(9): 1116-1118.
[12]	林友文, 黄尊行, 罗红斌. N－(4-羟基-3-甲氧基苯甲基）壳聚糖的制备及其水凝胶的pH敏感性[J]. 应用化学, 2006, 23(7): 770-775.
[13]	李良, 李国明, 黎茂荣, 容品加. 聚乳酸载力福平微球底制备及其释药性能[J]. 应用化学, 2003, 20(1): 65-68.
[14]	张春雪, 盛京, 马季涛. 交联补强硅橡胶包埋18-甲基炔诺酮的释放行为[J]. 应用化学, 2002, 19(6): 597-599.
[15]	原续波, 盛京, 严伟丽, 马季涛. 左旋18-甲基炔诺酮-硅橡胶缓释体系小角激光散射法研究[J]. 应用化学, 1998, 0(2): 28-31.