中华医学超声杂志

应用化学 ›› 2011, Vol. 28 ›› Issue (09): 1063-1066.DOI: 10.3724/SP.J.1095.2011.00610

• 研究论文 • 上一篇    下一篇

激光法测定硝唑尼特结晶介稳区间

赵地顺1*,吕斌2,寇成1,杨洁1,董兰芬1,张妍1   

  1. (河北科技大学1.化学与制药工程学院；2.理学院 石家庄 050018)
  • 收稿日期:2010-10-13 修回日期:2010-12-09 出版日期:2011-09-10 发布日期:2011-09-10
  • 通讯作者: 赵地顺，教授; Tel/Fax:0311-88632009; E-mail:dishunzhao@yahoo.com.cn; 研究方向：清洁能源化工与工业催化

Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method

ZHAO Dishun1*, LV Bin2, KOU Cheng1, YANG Jie1, DONG Lanfen1, ZHANG Yan1   

  1. (1.College of Chemistry and Pharmaceutical Engineering;2.College of Sciences,
    Hebei University of Science and Technology,Shijiazhuang 050018)
  • Received:2010-10-13 Revised:2010-12-09 Published:2011-09-10 Online:2011-09-10

PDF

1727

被引次数

5

摘要：

用激光法测定了不同温度下硝唑尼特在N,N-二甲基甲酰胺（DMF）、二甲基亚砜（DMSO）、甲醇和丙酮4种溶剂体系中的溶解度与超溶解度，得到硝唑尼特在不同溶剂和不同温度下的介稳区宽度。 结果表明，硝唑尼特在4种溶剂体系中的溶解度、超溶解度和介稳区宽度随温度升高逐渐增大。 在相同温度下，硝唑尼特在DMF、DMSO、甲醇和丙酮中介稳区宽度关系为：丙酮＜DMSO＜甲醇＜DMF。

关键词: 硝唑尼特, 溶解度, 超溶解度, 介稳区宽度

Abstract:

The saturated and supersaturated characteristics of nitazoxanide in DMF, DMSO, methanol and acetone at different temperatures were investigated by using the laser detection technique. The crystallization metastable zone widths of nitazoxanide were obtained at different temperatures in the above four solvents. The results indicated that the solubility, supersolubility and the metastable zone width of nitazoxanide enhance with increasing temperature. At the same temperature, the metastable zone width of nitazoxanide relations as follows:acetone＜DMSO＜methanol＜DMF.

Key words: nitazoxanide, solubility, supersolubility, metastable zone width

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