应用化学 ›› 2009, Vol. 26 ›› Issue (08): 894-898.

• 研究论文 • 上一篇    下一篇

超声辐射法在新型含双杂环芳酰基硫脲合成中的应用

孙文理,李燕萍*,刘晨江,李海龙   

  1. (新疆大学化学化工学院石油天然气精细化工教育部重点实验室 乌鲁木齐 830046)
  • 收稿日期:2008-07-23 修回日期:2008-10-27 出版日期:2009-08-10 发布日期:2009-08-10
  • 通讯作者: 李燕萍,女,副教授; E-mail:LYP_666@163.com; 研究方向:有机合成
  • 基金资助:
    校院联合资助项目(070196)

Application of Ultrasonic Irradiation in Synthesis of Novel Bis-heterocyclic aroylthioureas

SUN Wen-Li, LI Yan-Ping*, LIU Chen-Jiang, LI Hai-Long   

  1. (Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education,
    College of Chemistry and Chemical Engineering,Xinjiang University,Ulumqi 830046)
  • Received:2008-07-23 Revised:2008-10-27 Published:2009-08-10 Online:2009-08-10

摘要:

以2-苯基-1,2,3-三唑-4-甲酸、氨基硫脲为原料在三氯氧磷中反应得到2-氨基-5-(2-苯基-1,2,3-三唑-4-基)-1,3,4-噻二唑,然后分别采用超声辐射法和常规加热法与芳酰基异硫氰酸酯反应合成了一系列的N-[5-(2-苯基-1,2,3-三唑-4-基)1,3,4-噻二唑-2-基\]-N′-酰基硫脲。 通过与常规方法比较,采用超声辐射法反应时间只有原来的12.5%,反应产率提高了4%~17%,减少了副反应。 所有化合物的结构经元素分析、MS、IR、1H NMR测试技术确证。

关键词: 超声波辐射,芳酰基硫脲,噻二唑,苯接三唑

Abstract:

2-Amino-5-(2-phenyl-1,2,3-triazol-4-yl)-1,3,4-thiodiazole has been prepared by reaction of 2-phenyl-1,2,3-triazole-4-carboxylic acid with aminothiourea in the presence of phosphorus oxychloride. Then a series of novel N-[5-(2-phenyl-1,2,3-triazol-4-yl)-1,3,4-thiodiazol-2-yl]-N′-aroylthioureas have been synthesized by reaction of compound 1 with aroyl isothiocyanates by means of ultrasonic radiation method and ordinary method. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectroscopy.

Key words: ultrasonic radiation,aroyl thiourea,thiodiazole,phenyltriazole

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