树脂固载的β-酮砜的烷基化反应

摘要/Abstract

摘要： Samuelsson等由季铵盐、碱和β-酮砜化合物制得相应的β-酮砜阴离子季铵盐,可直接用于烷基化反应^[1]。此法较经典方法虽有条件温和,产率较高的优点,但分离麻烦,季铵盐用量大且不能回收.聚合物负载的季铵盐作为相转移催化剂和反应底物的载体,已用于含活泼亚甲基化合物的烷基化反应^[2-5].本文用离子交换法制得了大孔季铵盐离子固载的β-酮砜阴离子试剂,探索了这种试剂的烷基化反应条件,制得了一系列β-酮砜化合物的衍生物。

关键词: 强碱离子交换树脂, β-酮砜的烷基化, 聚合物负载试剂

Abstract: Polymer-bound α-carbanion of β-ketosulfone (2) was prepared by exchange reaction of strongly basic anion resin D296 (OH^- form) with α-pheny sulfonyl acetophenone (1).Several alkylated products of 2 were synthesized under anhydrous condition by polymer-supported carbanion with alkyl halides in good yields. The hydrolysis of the ester groupin the alkylating agent could be avoided in this process.

Key words: Polymer-bound carbanion agent, Alkylation of β-ketosulfone, Anion exchange resin

任启生, 黄文强, 陆宇, 尹耀荣, 何炳林. 树脂固载的β-酮砜的烷基化反应[J]. 应用化学, 1989, 0(4): 46-49.

Ren Qisheng, Huang Wenqiang, Lu Yu, Yin Yaorong, He Binglin. ALKYLATION OF POLYMER-BOUND α-CARBANION OF β-KETOSULFONE[J]. Chinese Journal of Applied Chemistry, 1989, 0(4): 46-49.

树脂固载的β-酮砜的烷基化反应

ALKYLATION OF POLYMER-BOUND α-CARBANION OF β-KETOSULFONE

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价