应用化学 ›› 1988, Vol. 0 ›› Issue (1): 71-73.

• 研究简报 • 上一篇    下一篇

醚型拟除虫菊酯的合成研究 Ⅰ.氯醚菊酯的合成

顾可权, 陈力, 张晓清   

  1. 华东师范大学化学系, 上海
  • 收稿日期:1987-05-25 修回日期:1987-07-04 出版日期:1988-02-10 发布日期:1988-02-10

SYNTHESIS OF ETHER-TYPE PYRETHROIDS Ⅰ.YNTHESIS OF CHLOPROXYFEN(MTI-501)

Gu Kequan, Chen Li, Zhang Xiaoquin   

  1. Department of Chemistry, East China Normal University, Shanghai
  • Received:1987-05-25 Revised:1987-07-04 Published:1988-02-10 Online:1988-02-10

摘要: 醚型拟除虫菊酯是近年来研究产生的新型菊酯类杀虫剂.这类化合物具有触杀及胃毒活性,对光热稳定,残效适中,对哺乳动物及鱼类低毒,是一类很有前途的农用杀虫剂.其中氯醚菊酯(Chloproxyfen)是日本三井东亚化学公司开发的醚菊酯—MTI-500(Ethoproxyfen)的类似物.

关键词: 拟除虫菊酯, 有机合成, 农药, Williamson反应

Abstract: The total synthesis of an ether-type pyrethroid, Chloproxyfen, is reported in this paper. Starting from chlorobenzene, the Chloproxyfen was synthesized through the Friedel-Crafts alkylation, free radical chlorination and improved Williamson etherification. High yields were achieved in each reaction process with the overall yield of 57.6%. The method is proved to be feasible for the industrial preparation.

Key words: Pyrethroid, Organic synthcsis, Agricultural drugs, Williamson's reaction