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生物材料用Mg-Y-Zn-Zr合金的微观结构及体外降解行为

范珺邱鑫1,3,田政1,张德平1,孙伟1,李扬德2,李卫荣2,孟健1*   

  1. (1.中国科学院长春应用化学研究所 长春 130022;
    2.东莞宜安科技股份有限公司 东莞 523000;3.中国科学院大学 北京 100049)
  • 收稿日期:2012-09-28 修回日期:2012-10-22 出版日期:2012-12-10 发布日期:2012-12-10
  • 通讯作者: 孟健，研究员; Tel/Fax:0431-85262030; E-mail:jmeng@ciac.jl.cn; 研究方向：稀土磁、电功能材料，稀土镁合金
  • 基金资助:
    国家科技支撑计划（2012BAE01B04，2011BAE22B01）和广东省201001C0104669453，2011A080403008资助项目

Microstructure and in Vitro Degradation Resistance of Mg-Y-Zn-Zr Alloys as Biomaterials

FAN Jun1,3, QIU Xin1, TIAN Zheng1, ZHANG Deping1, SUN Wei1, LI Yangde2, LI Weirong2, MENG Jian1*   

  1. (1.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;
    2.Dongguan Yian Science & Technology Co. Ltd,Dongguan 523000,China;
    3.University of Chinese Academy of Sciences,Beijing 100049,China)
  • Received:2012-09-28 Revised:2012-10-22 Published:2012-12-10 Online:2012-12-10
  • Contact: Jian Meng

PDF

1293

被引次数

2

摘要： 通过向纯镁中添加微量的合金化元素（Y、Zn和Zr），采用熔融浇铸法制备了名义成分为Mg1.5Y1.2Zn0.44Zr四元可降解镁合金生物材料，并对其进行了均匀化处理和挤压。 对这3种状态的镁合金进行了微观结构及在模拟体液(SBF)中体外降解行为的测试和分析，结果表明，合金主要由α-Mg基体和Mg12ZnY第二相组成；合金经过挤压后的组织得到了明显的细化；因此挤压后合金的降解性能得到明显改善；合金在模拟体液中生成的降解产物主要是含Ca和Mg的磷酸盐。

关键词: 生物材料, 稀土镁合金, 微观结构, 体外降解行为

Abstract: Mg-1.5Y-1.2Zn-0.44Zr alloys by adding small amounts(mass fraction) of yttrium(1.5%), zinc(1.2%) and zirconium(0.35%) into pure magnesium were developed as degradable metallic biomaterials. Also, solution treatment and hot extrusion were used as the methods for fabrication. An investigation of microstructure and in vitro degradation responses were made. The alloys are mainly composed of the matrix α-Mg phases and the Mg12ZnY secondary phases. The grains of the as-cast alloys were significantly refined by hot extrusion. The biodegradation resistance of the as-cast alloys is obviously improved by hot extrusion via microstructure refinement. The results of in vitro degradation responses in the simulated body fluid(SBF) indicate that the product of degradation precipitated on the alloy′s surface is the phosphate which contains Ca and Mg elements.

Key words: biomaterials, Mg-Y-Zn-Zr, microstructure, in vitro degradation

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