中华医学超声杂志

应用化学 ›› 2019, Vol. 36 ›› Issue (1): 120-122.DOI: 10.11944/j.issn.1000-0518.2019.01.180212

• 研究简报 • 上一篇    

臭氧化合成聚乙二醇醛基衍生物

吕文强ab,耿超a*(),徐经伟a*()   

  1. a中国科学院长春应用化学研究所,电分析化学国家重点实验室 长春 130022
    b中国科学院大学 北京 100049
  • 收稿日期:2018-06-13 接受日期:2018-09-12 出版日期:2019-01-01 发布日期:2019-01-04
  • 通讯作者: 耿超,徐经伟
  • 基金资助:
    国家自然科学基金(61504145)资助项目

Synthesis of Polyethylene Glycol Aldehyde Derivatives by Ozonation

LÜ Wenqiangab,GENG Chaoa*(),XU Jingweia*()   

  1. aState Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
    bUniversity of Chinese Academy of Sciences,Beijing 100049,China
  • Received:2018-06-13 Accepted:2018-09-12 Published:2019-01-01 Online:2019-01-04
  • Contact: GENG Chao,XU Jingwei
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.61504145)

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摘要：

以甲氧基聚乙二醇为原料, 通过烯烃化得到甲氧基聚乙二醇烯烃,最后经臭氧化反应得到甲氧基聚乙二醇醛基衍生物。 通过核磁共振波谱仪(NMR)和基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)对产物的结构和性能进行了表征。 结果表明,该方法合成的产物纯度高,无副产物,甲氧基聚乙二醇乙醛和聚乙二醇丙醛的产率分别高达98%和99%,取代度分别为90.87%~99.91%和98%~100%。

关键词: 聚乙二醇, 臭氧化, 醛基

Abstract:

Methoxypolyethylene glycol olefin was obtained by olefination of methoxypolyethylene glycol, and followed by ozonation to give methoxypolyethylene glycol aldehyde derivative. The properties of products were characterized by nuclear magnetic resonance spectroscopy(NMR) and matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS). The results show that the product has high purity and no by-products. The yields of methoxy polyethylene glycol acetaldehyde and polyethylene glycol propionaldehyde are as high as 98% and 99%, respectively, and the degrees of substitution are 90.87%~99.91% and 98%~100%, respectively.

Key words: polyethylene glycol, ozonation, aldehyde

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