金纳米粒子的细胞毒性

doi:10.11944/j.issn.1000-0518.2016.09.160075

摘要/Abstract

摘要：

金纳米粒子(AuNPs)是构建用于诊断和治疗的纳米药物/探针的理想纳米材料之一,因此研究AuNPs与细胞的相互作用具有重要意义。本文详细分析了金纳米簇(AuNCs)、球形金纳米粒子A(AuNPss)、金纳米球壳(AuNSs)和金纳米棒(AuNRs)等不同形貌的Au NPs对不同细胞模型的细胞毒性;讨论了AuNPs的理化性质(大小、形状、化学功能和表面电荷)对其细胞毒性的影响。总结了AuNP细胞毒性研究遇到的挑战并提出相应解决方法。

关键词: 金纳米粒子, 哺乳动物细胞, 细胞毒性, 生物效应

Abstract:

Gold nanoparticles(AuNPs) are one of ideal nanomaterials for constructing diagnostic and therapeutic nanosystems. Therefore, it is important to understand interactions of AuNPs and cells. In this review, we present a detailed analysis of data on the cytotoxicity of most popular AuNPs including gold nanoclusters(AuNCs), spherical AuNPs(AuNPss), gold nanoshells(AuNSs) and gold nanorods(AuNRs). We discuss the effects of the cell models, physicochemical properties(size, shape, chemical functionality, and surface charge) of AuNPs on the cytotoxicity of AuNPs. Some general conclusions, current challenges and future prospects/solutions on the issue have been provided.

Key words: gold nanoparticles, mammalian cells, cytotoxicity, biological effect

李铸衡,马立娜,刘殿骏,王振新. 金纳米粒子的细胞毒性[J]. 应用化学, 2016, 33(9): 1009-1016.

LI Zhuheng,MA Lina,LIU Dianjun,WANG Zhenxin. Cytotoxicity of Gold Nanoparticles[J]. Chinese Journal of Applied Chemistry, 2016, 33(9): 1009-1016.

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