Abstract: Daunorubicin(DNR) is a potent anti-leukemia agent. However, it also has cardiac, genic and genital toxicities. Thus, the study on the dosage of DNR and the establishment of various kinds of the determination methods of DNR has the very important and practical significance in the clinical medicine. This paper investigated the electrochemical performance of DNR at the β-cyclodextrin (β-CD) modified electrode. It was found that DNR can be complexed with β-CD modified on the electrode. The complexing constant is 6.1×104 L•mol-1. Furthermore, only DNR complexed in β-CD can undergo the irreversible electrochemical reaction. Its rate constant is 28.03 s-1. The cathodic peak current of DNR is proportional to the concentration of DNR in the 3-30 μmol• L-1 concentration range. Therefore, the β-CD modified electrode can be used to quantitative determination of DNR. When the pH of the electrolyte is 7.0 and the temperature is close to 40℃ the electrochemical activity of DNR at the β-CD modified electrode is best. At these conditions, the detection limit of DNR at the β-CD modified electrode is low.

Key words: Daunorubicin, β-cyclodextrin, modified electrode, complex