Application of Photoresponsive Behavior of Metal Nanoclusters in Biomedical Diagnostics and Therapy

doi:10.19894/j.issn.1000-0518.240079

Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (9): 1238-1247.DOI: 10.19894/j.issn.1000-0518.240079

• Review • Previous Articles

Application of Photoresponsive Behavior of Metal Nanoclusters in Biomedical Diagnostics and Therapy

Le HONG¹, Wei-Nan DONG², Zhen-Nan WU²(), Lin WANG¹()

^1.School of Stomatology，Jilin University，Changchun 130021，China
^2.State Key Laboratory on Integrated Optoelectronics，College of Electronic Science and Engineering，Jilin University，Changchun 130012，China

Received:2024-03-19 Accepted:2024-04-18 Published:2024-09-01 Online:2024-10-09
Contact: Zhen-Nan WU,Lin WANG
About author:wuzn@jlu.edu.cn
wanglin1982@jlu.edu.cn；
Supported by:
the National Natural Science Foundation of China(82170998)

Abstract

Abstract:

Metal nanoclusters， due to their unique photophysical properties， exhibit tremendous potential applications in the biomedical fields of biosensing， bioimaging， and photodynamic and photothermal therapies. This review systematically discusses the photoreactive behavior and application progress of metal nanoclusters in biomedical diagnostics and treatment， especially the electronic behavior after photosensitization treatment and their roles in various biomedical applications. Initially， the review introduces the electronic transition processes of metal nanoclusters after absorbing light energy， along with their applications in biosensing and imaging. Subsequently， the review analyzes the mechanisms of action of metal nanoclusters in photodynamic and photothermal therapies. Lastly， the review proposes the prospects and challenges of metal nanoclusters in biomedical applications， with the hope of providing a reference for further research and application of metal nanocluster materials.

Key words: Metal nanoclusters, Photoresponsive behavior, Photodynamic therapy, Optical imaging, Photothermal therapy

CLC Number:

O614

Le HONG, Wei-Nan DONG, Zhen-Nan WU, Lin WANG. Application of Photoresponsive Behavior of Metal Nanoclusters in Biomedical Diagnostics and Therapy[J]. Chinese Journal of Applied Chemistry, 2024, 41(9): 1238-1247.

Figures/Tables 5

Fig.1 Overview of the photoresponsive behavior of metal nanoclusters for biomedical applications

Fig.2 Schematic representation of bilayer ligand gold nanoclusters for the detection of arginase［35］

Fig.3 Schematic of trypsin-stabilized gold nanoclusters modified with folic acid for tumor imaging［49］

Fig.4 Scheme of captopril-protected gold nanoclusters can generate single-linear oxygen upon light［55］

Fig.5 Scheme of gold nanoclusters of hybrid albumin nanoparticles as a tool for fluorescence imaging and tumor treatment［62］

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Application of Photoresponsive Behavior of Metal Nanoclusters in Biomedical Diagnostics and Therapy

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