Research Progress on Small Molecule Anticancer Drug Release System Based on Fluorescence Effect

doi:10.11944/j.issn.1000-0518.2019.07.190040

Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (7): 733-748.DOI: 10.11944/j.issn.1000-0518.2019.07.190040

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Research Progress on Small Molecule Anticancer Drug Release System Based on Fluorescence Effect

ZHANG Jidong(),LI Jiayuan,JIN Huafeng

School of Chemistry & Chemical Engineering,Ankang Univerisity,Ankang,Shannxi 725000,China

Received:2019-02-18 Accepted:2019-04-30 Published:2019-07-01 Online:2019-07-02
Contact: ZHANG Jidong
Supported by:
Supported by the Key Projects of Shaanxi Provincial Science & Technology Department(No.2018PT-31), Major Scientific Research Projects of the Leading Industry of Ankang City(No.2016AKZDCY002), Scientific Research Foundation for Advanced Talents of Ankang University(No.2018AYQDZR06), Key Laboratory of Se-Enriched Products Development and Quality Control, Ministry of Agriculture(No.Se-2018B02), the Shaanxi Provincial Innovation Experiment Program for University Students(No.201839032)

Abstract

Abstract:

In recent years, with the rising incidence of cancer, the renewal and development of cancer therapy technology is particularly important. Especially, the introduction of chemotherapy has promoted the research for the release system of fluorescence small molecule anticancer drugs. An anticancer drug release system combines organic fluorescent molecules with anticancer drugs based on fluorescent effect, which has the characteristics of low toxicity, excellent targeting to cancer cells and convenience to track and monitor. Therefore, design of prodrugs with different properties can be used to study the kinetic process of the release of anticancer drugs and provide a powerful tool for the accurate treatment for cancers. This paper mainly introduces the research progress of prodrugs based on camptothecin, SN-38 and adriamycin, and the prospects for their development.

Key words: drug release, chemotherapy, cancer treatment, camptothecin, fluorescence small molecular

ZHANG Jidong,LI Jiayuan,JIN Huafeng. Research Progress on Small Molecule Anticancer Drug Release System Based on Fluorescence Effect[J]. Chinese Journal of Applied Chemistry, 2019, 36(7): 733-748.

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Research Progress on Small Molecule Anticancer Drug Release System Based on Fluorescence Effect

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